JAK/HDAC-IN-1 Inhibitor

Name: JAK/HDAC-IN-1 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5755013
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755013

JAK/HDAC-IN-1 is an effective JAK2/HDAC dual inhibitor (IC50s: 4 and 2nM for JAK2 and HDAC). It also shows antiproliferative and proapoptotic activities in several hematological cell lines. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

JAK/HDAC-IN-1, Inhibitor

Full Product Name

JAK/HDAC-IN-1

Product Gene Name

JAK/HDAC-IN-1, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

450.32

Solubility

DMSO: 20.83mg/mL (46.26mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C19H21Cl2N7O2

SMILES

ClC1=CC=C(NC2=NC(NC3=CN(CCCCCC(NO)=O)N=C3)=NC=C2Cl)C=C1

CAS Number

2284621-75-4

Target & IC50

JAK2: ic50 4nM
JAK1: ic50 4.8nM
JAK3: ic50 7.4nM
Tyk2: ic50 49nM
HDAC: ic50 2nM
HDAC2: ic50 14nM
HDAC6: ic50 120nM
HDAC8: ic50 2470nM

In Vitro

JAK/HDAC-IN-1 shows IC50s of 4.8, 7.4, and 49nM for JAK1, JAK3, and TYK2, and 14, 120, 2470nM for HDAC2, HDAC6 and HDAC8, respectively[1].

Product Categories/Family for JAK/HDAC-IN-1, inhibitor

Stem Cells; Chromatin/Epigenetic; Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors; DNA Damage/DNA Repair

Product References and Citations for JAK/HDAC-IN-1, inhibitor

Liang X, et al. Discovery of Novel Janus Kinase (JAK) and Histone Deacetylase (HDAC) Dual Inhibitors for the treatment,of Hematological Malignancies. J Med Chem. 2019 Apr 25;62(8):3898-3923.
Liang X, et al. Discovery of Novel Janus Kinase (JAK) and Histone Deacetylase (HDAC) Dual Inhibitors for the treatment,of Hematological Malignancies. J Med Chem. 2019 Apr 25;62(8):3898-3923.

Other Notes

Small volumes of JAK/HDAC-IN-1, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for JAK/HDAC-IN-1 purchase

MBS5755013 is an inhibitor targeting JAK/HDAC-IN-1.