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JND3229 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755022

JND3229 is a highly potent and fourth-generation EGFRC797S reversible inhibitor (IC50: 5.8nM). It also effectively suppressed EGFRL858R/T790M and EGFRWT (IC50: 30.5 and 6.8nM). More details

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Product Documentation
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Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
JND3229, Inhibitor
Full Product Name
JND3229
Product Gene Name
JND3229, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
617.18
Solubility
DMSO: 12.5mg/mL (20.25mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C33H41ClN8O2
SMILES
CC1=CC(NC2=NC(N([C@@H]3CC[C@@H](NC(CC)=O)CC3)C(N(C4=C(Cl)C=CC=C4)C5)=O)=C5C=N2)=CC=C1N6CCN(C)CC6
CAS Number
2260886-64-2
Target & IC50
Others

Structure of JND3229, inhibitor

JND3229 Inhibitor – Cat# MBS5755022

Product References and Citations for JND3229, inhibitor

Lu X, et al. Discovery of JND3229 as a New EGFRC797S Mutant Inhibitor with In Vivo Monodrug Efficacy. ACS Med Chem Lett. 2018 Oct 8;9(11):1123-1127.
Lu X, et al. Discovery of JND3229 as a New EGFRC797S Mutant Inhibitor with In Vivo Monodrug Efficacy. ACS Med Chem Lett. 2018 Oct 8;9(11):1123-1127.

Other Notes

Small volumes of JND3229, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for JND3229 purchase

MBS5755022 is an inhibitor targeting JND3229.
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