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CD1E Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9606012

Function: T-cell surface glycoprotein CD1e, soluble binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids, and is required for the presentation of glycolipid antigens on the cell surface. The membrane-associated form is… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD1E, Polyclonal Antibody
Full Product Name
CD1E Antibody
Product Gene Name
anti-CD1E antibody
Product Synonym Names
CD_antigen=CD1e; CD1A; CD1e; CD1e antigen; CD1E antigen, e polypeptide; CD1e molecule; CD1E_HUMAN; Differentiation antigen CD1-alpha-3; hCD1e; Leukocyte differentiation antigen; R2; R2G1; sCD1e; soluble; T-cell surface glycoprotein CD1e; T-cell surface glycoprotein CD1e, membrane-associated; T-cell surface glycoprotein CD1e, soluble
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Concentration
1mg/ml (lot specific)
Specificity
CD1E antibody detects endogenous levels of total CD1E
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Antibody/Peptide Pairs
CD1E peptide (MBS9624729) is used for blocking the activity of CD1E antibody (MBS9606012)
Molecular Weight
Observed: 36 kD
Predicted: 44 kDa
3D Structure
ModBase 3D Structure for P15812
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Immunogen
A synthesized peptide
Subcellular Location
Endosome; Golgi Apparatus; Lysosome
Tissue Specificity
Expressed on cortical thymocytes, dendritic cells, Langerhans cells, on certain T-cell leukemias, and in various other tissues.
Predicted Cross Reactivity
Pig, Dog
Similarity
Pig (80%), Dog (90%)
Conjugation
Unconjugated
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-CD1E antibody
Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA)
Application Notes for anti-CD1E antibody
WB: 1:500-1:1000
IF/ICC: 1:100-1:500

Western Blot (WB) of anti-CD1E antibody

Western blot analysis of extracts from HuvEc cells using CD1E antibody.
Rabbit Anti-CD1E Polyclonal Antibody – Cat# MBS9606012

Immunofluorescene (IF) of anti-CD1E antibody

MBS9606012 staining HepG2 cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25 degree C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37 degree C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody, diluted at 1/600, was used as secondary antibody.
Rabbit Anti-CD1E Polyclonal Antibody, Immunofluorescene (IF) – Cat# MBS9606012

Other Notes

Small volumes of anti-CD1E antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD1E purchase

MBS9606012 is an antibody targeting CD1E. Also known as CD1E Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CD1E. It may not necessarily be applicable to this product.

NCBI GI #
110618230
NCBI GeneID
913
NCBI Accession #
NP_001036048.1
UniProt Primary Accession #
P15812
UniProt Secondary Accession #
Q5TDJ9; Q5TDK3; Q5TDK4; Q5TDK5; Q5TDK6; Q5TDK8; Q5TDL1; Q712E4; Q712E5; B4DZV3; E7EP01
UniProt Related Accession #
P15812
GenBank Nucleotide #
NM_001042583.2
NCBI Official Full Name
T-cell surface glycoprotein CD1e, membrane-associated isoform b
NCBI Official Synonym Full Names
CD1e molecule
NCBI Official Symbol
CD1E
NCBI Official Synonym Symbols
R2; CD1A
UniProt Protein Name
T-cell surface glycoprotein CD1e, membrane-associated
UniProt Synonym Protein Names
R2G1; CD_antigen: CD1e
Protein Family
T-cell surface glycoprotein
UniProt Gene Name
CD1E
UniProt Synonym Gene Names
hCD1e; sCD1e
NCBI Protein Information
T-cell surface glycoprotein CD1e, membrane-associated

NCBI Summary for CD1E

This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes within Golgi compartments, endosomes, and lysosomes, and is cleaved into a stable soluble form. The soluble form is required for the intracellular processing of some glycolipids into a form that can be presented by other CD1 family members. Many alternatively spliced transcript variants encoding different isoforms have been described. Additional transcript variants have been found; however, their biological validity has not been determined. [provided by RefSeq, Jun 2010]
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UniProt Comments for CD1E

T-cell surface glycoprotein CD1e, soluble binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids, and is required for the presentation of glycolipid antigens on the cell surface. The membrane-associated form is not active.

Research Articles on CD1E

1. There was no association between polymorphisms of CD1E genes and the susceptibilities to Guillain-Barre syndrome.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CD1E antibody

 Products by Pathway  Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram

Diseases associated with anti-CD1E antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >8 publications with CD1E and Nervous System Diseases
 Neoplasms Antibodies  >3 publications with CD1E and Neoplasms
 Lung Diseases Antibodies  >1 publications with CD1E and Lung Diseases

Organs/Tissues associated with anti-CD1E antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >11 publications with CD1E and Blood
 Thymus Antibodies  >3 publications with CD1E and Thymus
 Lung Antibodies  >2 publications with CD1E and Lung
 Liver Antibodies  >1 publications with CD1E and Liver
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