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MK-0343 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755192

MK0343 is an orally bioavailable GABAA receptor subtype-selective partial agonist and is a non-sedating anxiolytic. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MK-0343, Inhibitor
Full Product Name
MK-0343
Product Gene Name
MK-0343, inhibitor
Product Synonym Names
MRK-409
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
397.38
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C19H17F2N7O
SMILES
CN1N=CN=C1COC2=NN3C(C=C2C4CCC4)=NN=C3C5=C(F)C=CC=C5F
CAS Number
233275-76-8
Target & IC50
rGABAA alpha1: ic500.22nM (ki)
rGABAAalpha2: ic50 0.4nM (ki)
rGABAAalpha3: ic50 0.21nM (ki)
rGABAAalpha4: ic50 78nM (ki)
rGABAAalpha5: ic50 0.23nM (ki)
rGABAAalpha6: ic50 980nM (ki)

Structure of MK-0343, inhibitor

MK-0343 Inhibitor – Cat# MBS5755192

Product References and Citations for MK-0343, inhibitor

Atack JR, et al. MRK-409 (MK-0343), a GABAA receptor subtype-selective partial agonist, is a non-sedating anxiolytic in preclinical species but causes sedation in humans. J Psychopharmacol. 2011 Mar;25(3):314-28.

Other Notes

Small volumes of MK-0343, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MK-0343 purchase

MBS5755192 is an inhibitor targeting MK-0343.
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