FPGS Antibody – Rabbit Polyclonal

This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]

FPGS: Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstitued reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates. Belongs to the folylpolyglutamate synthase family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Ligase; Mitochondrial; Cofactor and Vitamin Metabolism - folate biosynthesis; EC 6.3.2.17

Chromosomal Location of Human Ortholog: 9q34.1

Cellular Component: mitochondrion; mitochondrial matrix; mitochondrial inner membrane; cytoplasm; cytosol

Molecular Function: tetrahydrofolylpolyglutamate synthase activity; ATP binding

Biological Process: organ regeneration; vitamin metabolic process; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; tetrahydrofolylpolyglutamate biosynthetic process; brain development; folic acid metabolic process; one-carbon compound metabolic process; liver development; water-soluble vitamin metabolic process