Phorbol 12,13-dibutyrate Inhibitor

Name: Phorbol 12,13-dibutyrate Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5755375
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755375

Phorbol 12,13-dibutyrate is a PKC activator. It also is a potent skin tumor promoter. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Phorbol 12,13-dibutyrate, Inhibitor

Full Product Name

Phorbol 12,13-dibutyrate

Product Synonym Names

Phorbol dibutyrate; PDBu

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

504.61

Solubility

DMSO: 125mg/mL (247.72mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C28H40O8

SMILES

O=C1C(C)=C[C@@]2([H])[C@]3(O)[C@@]([C@@](C4(C)C)([H])[C@@]4(OC(CCC)=O)[C@H](OC(CCC)=O)[C@H]3C)([H])C=C(CO)C[C@]12O

CAS Number

37558-16-0

Target & IC50

PKC

In Vitro

Phorbol 12,13-dibutyrate (1mM) activates PKC. It also inhibited Na/K-ATPase transport activity in OK cells[3].

Product Categories/Family for Phorbol 12,13-dibutyrate, inhibitor

Cytoskeletal Signaling; PKC

Product References and Citations for Phorbol 12,13-dibutyrate, inhibitor

Singh J, et al. Immunocytochemical evidence for PDBu-induced activation of RhoA/ROCK in human internal anal sphincter smooth muscle cells. Am J Physiol Gastrointest Liver Physiol. 2011 Aug;301(2):G317-25.
Singh J, et al. Immunocytochemical evidence for PDBu-induced activation of RhoA/ROCK in human internal anal sphincter smooth muscle cells. Am J Physiol Gastrointest Liver Physiol. 2011 Aug;301(2):G317-25.
Szallasi Z, et al. Dissociation of phorbol esters leads to immediate redistribution to the cytosol of protein kinases C alpha and C delta in mouse keratinocytes. J Biol Chem. 1994 Nov 4;269(44):27159-62.
Szallasi Z, et al. Dissociation of phorbol esters leads to immediate redistribution to the cytosol of protein kinases C alpha and C delta in mouse keratinocytes. J Biol Chem. 1994 Nov 4;269(44):27159-62.
Middleton JP, et al. Heterogeneity of protein kinase C-mediated rapid regulation of Na/K-ATPase in kidney epithelial cells. J Biol Chem. 1993 Jul 25;268(21):15958-64.
Middleton JP, et al. Heterogeneity of protein kinase C-mediated rapid regulation of Na/K-ATPase in kidney epithelial cells. J Biol Chem. 1993 Jul 25;268(21):15958-64.

Other Notes

Small volumes of Phorbol 12,13-dibutyrate, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

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MBS5755375 is an inhibitor targeting Phorbol 12,13-dibutyrate.