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PPADS Inhibitor – Tetrasodium

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755402

PPADS tetrasodiuma is an inhibitor of the reverse mode of the Na/Ca^2+ exchanger in guinea pig airway smooth muscle. PPADS tetrasodiuma is a non-selective P2X receptor antagonist. PPADS tetrasodiuma blocks recombinant P2X1, -2, -3, -5 (IC50s ranging from 1 to… More details

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Product Overview

Online Datasheet in PDF
Product Name
PPADS tetrasodium, Inhibitor
Full Product Name
PPADS tetrasodium
Product Gene Name
PPADS, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
599.3
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C14H10N3Na4O12PS2
SMILES
O=S(C1=CC=C(/N=N/C2=NC(C)=C(O)C(C=O)=C2COP([O-])([O-])=O)C(S(=O)([O-])=O)=C1)([O-])=O.[Na+].[Na+].[Na+].[Na+]
CAS Number
192575-19-2
Target & IC50
Others
In Vitro
PPADS tetrasodiuma (15-60mg/100g body weight (BW); i.p.; every 12 hours for 8 days) inhibits glomerular mesangial cells (MC) proliferation. It also not altering the proliferation of non-MC in vivo in mesangial proliferative glomerulonephritis[4].

Structure of PPADS, inhibitor

PPADS Inhibitor – Cat# MBS5755402

Product References and Citations for PPADS, inhibitor

Flores-Soto E, et al. PPADS, a P2X receptor antagonist, as a novel inhibitor of the reverse mode of the Na+ /Ca^2+ exchanger in guinea pig airway smooth muscle. Eur J Pharmacol. 2012 Jan 15;674(2-3):439-44.
Flores-Soto E, et al. PPADS, a P2X receptor antagonist, as a novel inhibitor of the reverse mode of the Na+ /Ca^2+ exchanger in guinea pig airway smooth muscle. Eur J Pharmacol. 2012 Jan 15;674(2-3):439-44.
Huo H, et al. Mapping the binding site of the P2X receptor antagonist PPADS reveals the importance of orthosteric site charge and the cysteine-rich head region. J Biol Chem. 2018 Aug 17;293(33):12820-12831.
Huo H, et al. Mapping the binding site of the P2X receptor antagonist PPADS reveals the importance of orthosteric site charge and the cysteine-rich head region. J Biol Chem. 2018 Aug 17;293(33):12820-12831.
Einfluss von ATP und seinen Derivaten auf die Aktivierung von Monozyten.
Einfluss von ATP und seinen Derivaten auf die Aktivierung von Monozyten.
Rost S, et al. P2 receptor antagonist PPADS inhibits mesangial cell proliferation in experimental mesangialproliferative glomerulonephritis. Kidney Int. 2002 Nov;62(5):1659-71.
Rost S, et al. P2 receptor antagonist PPADS inhibits mesangial cell proliferation in experimental mesangialproliferative glomerulonephritis. Kidney Int. 2002 Nov;62(5):1659-71.

Other Notes

Small volumes of PPADS, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PPADS purchase

MBS5755402 is an inhibitor targeting PPADS. Also known as PPADS tetrasodium.
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