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QC6352 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755431

MBS5755431 is an inhibitor targeting QC6352. QC6352 is a selective and effective KDM4C inhibitor (IC50: 35nM). More details

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Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
QC6352, Inhibitor
Full Product Name
QC6352
Product Gene Name
QC6352, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
387.47
Solubility
DMSO: 25mg/mL (64.52mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C24H25N3O2
SMILES
O=C(C1=C(NC[C@@H]2CCCC3=C2C=CC(N(C)C4=CC=CC=C4)=C3)C=NC=C1)O
CAS Number
1851373-36-8
Target & IC50
KDM4C: ic50 35nM
In Vitro
QC6352 strongly affects tumor growth and the final tumor weight of both BCSC1 and BCSC2 xenografts. QC6352 treatment is well tolerated and does not affect body weight of the mice. Treatment with the KDM4 inhibitor QC6352 blocks BCSC xenograft tumor growth[2].

Product Categories/Family for QC6352, inhibitor

Chromatin/Epigenetic; Histone Demethylase; Epigenetics

Structure of QC6352, inhibitor

QC6352 Inhibitor – Cat# MBS5755431

Product References and Citations for QC6352, inhibitor

Chen YK, et al. Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models. ACS Med Chem Lett. 2017 Jul 27;8(8):869-874.
Chen YK, et al. Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models. ACS Med Chem Lett. 2017 Jul 27;8(8):869-874.
Metzger E, et al. KDM4 inhibition targets breast cancer stem-like cells. Cancer Res. 2017 Sep 7. pii: canres.1754.
Metzger E, et al. KDM4 inhibition targets breast cancer stem-like cells. Cancer Res. 2017 Sep 7. pii: canres.1754.

Other Notes

Small volumes of QC6352, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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