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RhebNR1 Inhibitor – Rheb NR1

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755449

Rheb inhibitor NR1 inhibits the phosphorylation of T389pS6K1 and increases the phosphorylation of S473pAKT in a dose-dependent manner. Rheb inhibitor NR1 is a Rheb inhibitor (IC50: 2.1epsilonM in the Rheb-IVK assay). NR1 also is a selective mTORC1 inhibitor. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Rheb NR1 (RhebNR1), Inhibitor
Full Product Name
Rheb inhibitor NR1
Product Gene Name
RhebNR1, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
578.3
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C25H19BrCl2N2O3S
SMILES
O=C(C(N1CC2=CC=C(C(N(C)C)=O)C=C2)=CC3=C1C=C(SC4=CC=C(Cl)C(Cl)=C4)C=C3Br)O
CAS Number
2216763-38-9
Target & IC50
Others

Structure of RhebNR1, inhibitor

RhebNR1 Inhibitor – Cat# MBS5755449

Product References and Citations for RhebNR1, inhibitor

Mahoney SJ, et al. A small molecule inhibitor of Rheb selectively targets mTORC1 signaling. Nat Commun. 2018 Feb 7;9(1):548.
Mahoney SJ, et al. A small molecule inhibitor of Rheb selectively targets mTORC1 signaling. Nat Commun. 2018 Feb 7;9(1):548.

Other Notes

Small volumes of RhebNR1, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RhebNR1 purchase

MBS5755449 is an inhibitor targeting RhebNR1. Also known as Rheb inhibitor NR1.
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