ubiquitin specific protease 3 fragment Inhibitor

Solid. Powder

98.00%

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

937.07

DMSO: >=93.7mg/mL
DMSO: >=93.7mg/mL
(<1mg/ml refers to the product slightly soluble or insoluble)

C38H68N10O15S

NC(CO)C(NC(C(O)C)C(NC(C(C)O)C(NC(C)C(NC(C(C)CC)C(NC(CS)C(NC(C)C(NC(C(O)C)C(NCC(NC(CC(C)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

USP3 dynamically associates with chromatin and deubiquitinates H2A/H2B in vivo. The ZnF-UBP domain of USP3 mediates uH2AUSP3 interaction. Functional ablation of USP3 by RNAi leads to delay of S phase progression and to the accumulation of DNA breaks, with ensuing activation of DNA damage checkpoint pathways. In response to ionizing radiation, (1) uH2A redistributes and colocalizes in g-H2AX DNA repair foci, and (2) USP3 is required for full deubiquitination of ubiquitin-conjugates/uH2A and g-H2AX dephosphorylation. USP3 is a novel regulator of H2A and H2B ubiquitination, highlight its role in preventing replication stress and suggest its involvement in the response to DNA double-strand breaks1.