PF-AKT400 Inhibitor

MBS5758232 is an inhibitor targeting PF-AKT400. PF-AKT400 is a broadly selective and ATP-competitive inhibitor of Akt.

Freeman-Cook KD, et al. Design of selective, ATP-competitive inhibitors of Akt. J Med Chem. 2010 Jun 24;53(12):4615-4622.
Freeman-Cook KD, et al. Design of selective, ATP-competitive inhibitors of Akt. J Med Chem. 2010 Jun 24;53(12):4615-4622.
Chen SF, et al. Binding selectivity studies of PKBalpha using molecular dynamics simulation and free energy calculations. J Mol Model. 2013 Nov;19(11):5097-5112.
Chen SF, et al. Binding selectivity studies of PKBalpha using molecular dynamics simulation and free energy calculations. J Mol Model. 2013 Nov;19(11):5097-5112.

Small volumes of PF-AKT400, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.