Didox Inhibitor

Didox is a synthetic ribonucleotide reductase (RR) inhibitor that has been found to reduce the levels of oxidative injury markers in the brains of HIV patients with dementia.

Asperti M, Cantamessa L, Ghidinelli S,et al. The Antitumor Didox Acts as an Iron Chelator in Hepatocellular Carcinoma Cells[1].Pharmaceuticals (Basel). 2019 Sep 2;12(3).
Asperti M, Cantamessa L, Ghidinelli S,et al. The Antitumor Didox Acts as an Iron Chelator in Hepatocellular Carcinoma Cells[1].Pharmaceuticals (Basel). 2019 Sep 2;12(3).
Mcleod J J A, Caslin H L, Spence A J, et al. Didox (3,4-dihydroxybenzohydroxamic acid) suppresses IgE-mediated mast cell activation through attenuation of NFkappaB and AP-1 transcription[J]. Cellular Immunology, 2017:S0008874917301442.
Mcleod J J A, Caslin H L, Spence A J, et al. Didox (3,4-dihydroxybenzohydroxamic acid) suppresses IgE-mediated mast cell activation through attenuation of NFkappaB and AP-1 transcription[J]. Cellular Immunology, 2017:S0008874917301442.
Matsebatlela TM, et al. 3,4-Dihydroxy-benzohydroxamic acid (Didox) suppresses pro-inflammatory profiles and oxidative stress in TLR4-activated RAW264.7 murine macrophages. Chem Biol Interact. 2015 May 25;233:95-105.

Small volumes of Didox, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5758416 is an inhibitor targeting Didox.