Saquinavir Inhibitor

Name: Saquinavir Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5758765
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5758765

Saquinavir is a potent HIV protease inhibitor, is an antiretroviral drug used together with other medications to treat or prevent HIV/AIDS. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Saquinavir, Inhibitor

Full Product Name

Saquinavir

Product Synonym Names

Ro 31-8959

Form/Format

Solid. Powder

Purity/Purification

100.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

670.84

Solubility

DMSO: 100mg/mL (149.07mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C38H50N6O5

SMILES

CC(C)(C)NC(=O)C1CC2CCCCC2CN1CC(O)C(Cc1ccccc1)NC(=O)C(CC(N)=O)NC(=O)c1ccc2ccccc2n1

CAS Number

127779-20-8

Target & IC50

HIV Protease

In Vitro

The AUC was not affected by grapefruit juice after intravenous administration, but it increased significantly from 76+/-96 (water, mean (s.d.) to 114+/-70 (microg l[-1] h) (grapefruit juice) after oral saquinavir. Similarly, the oral bioavailability of saquinavir increased by a factor of 2 with grapefruit juice (from 0.7% to 1.4%). In contrast, clearance, volume of distribution and elimination half-life of saquinavir were not affected by grapefruit juice. After oral, but not after intravenous administration, the plasma concentration-time curve showed a second peak after lunch irrespective of pretreatment, suggesting enhancement of absorption by food[1].

Product Categories/Family for Saquinavir, inhibitor

Microbiology/Virology; HIV Protease; Proteases/Proteasome

Product References and Citations for Saquinavir, inhibitor

Kupferschmidt H H T, Fattinger K E, Ha H R, et al. Grapefruit juice enhances the bioavailability of HIV protease inhibitor saquinavir in man[J]. British Journal of Clinical Pharmacology, 1998, 45(4):355-359.
Kupferschmidt H H T, Fattinger K E, Ha H R, et al. Grapefruit juice enhances the bioavailability of HIV protease inhibitor saquinavir in man[J]. British Journal of Clinical Pharmacology, 1998, 45(4):355-359.
Walmsley S, Avihingsanon A, Slim J, et al. Gemini: A Noninferiority Study of Saquinavir/Ritonavir Versus Lopinavir/Ritonavir as Initial HIV-1 Therapy in Adults[J]. JAIDS Journal of Acquired Immune Deficiency Syndromes, 2009, 50(4):367-374.
Walmsley S, Avihingsanon A, Slim J, et al. Gemini: A Noninferiority Study of Saquinavir/Ritonavir Versus Lopinavir/Ritonavir as Initial HIV-1 Therapy in Adults[J]. JAIDS Journal of Acquired Immune Deficiency Syndromes, 2009, 50(4):367-374.

Other Notes

Small volumes of Saquinavir, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Saquinavir purchase

MBS5758765 is an inhibitor targeting Saquinavir.