Selpercatinib Inhibitor

Name: Selpercatinib Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5759035
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5759035

Selpercatinib is a tyrosine kinase inhibitor with antineoplastic properties(IC50 of 14.0nM, 24.1nM, and 530.7nM for RET (WT), RET (V804M), and RET (G810R), respectively) More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Selpercatinib, Inhibitor

Full Product Name

Selpercatinib

Product Synonym Names

LOXO-292

Form/Format

Solid. Powder

Purity/Purification

100.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

525.60

Solubility

DMSO: 8.33mg/mL (15.85mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C29H31N7O3

SMILES

COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(OCC(C)(C)O)cn3ncc(C#N)c23)cn1

CAS Number

2152628-33-4

Target & IC50

RET (WT): ic50 14.0nM
RET (V804M): ic50 24.1nM
RET (G810R): ic50 530.7nM

Product Categories/Family for Selpercatinib, inhibitor

Apoptosis; c-RET; Tyrosine Kinase/Adaptors

Product References and Citations for Selpercatinib, inhibitor

Steven W. Andrews, et al. Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors. WO2018071447A1.

Other Notes

Small volumes of Selpercatinib, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Selpercatinib purchase

MBS5759035 is an inhibitor targeting Selpercatinib.