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SPDEF cDNA Clone – SAM Pointed Domain Containing Ets Transcription Factor (Human)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1278768

MBS1278768 is a cDNA clone targeting SPDEF. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
PDF
Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SPDEF, cDNA Clone
Full Product Name
SPDEF cDNA Clone
Product Gene Name
SPDEF cdna clone
Sequence
atgggcagcg ccagcccggg tctgagcagc gtatccccca gccacctcct gctgcccccc gacacggtgt cgcggacagg cttggagaag gcggcagcgg gggcagtggg tctcgagaga cgggactgga gtcccagtcc acccgccacg cccgagcagg gcctgtccgc cttctacctc tcctactttg acatgctgta ccctgaggac agcagctggg cagccaaggc ccctggggcc agcagtcggg aggagccacc tgaggagcct gagcagtgcc cggtcattga cagccaagcc ccagcgggca gcctggactt ggtgcccggc gggctgacct tggaggagca ctcgctggag caggtgcagt ccatggtggt gggcgaagtg ctcaaggaca tcgagacggc ctgcaagctg ctcaacatca ccgcagatcc catggactgg agccccagca atgtgcagaa gtggctcctg tggacagagc accaataccg gctgcccccc atgggcaagg ccttccagga gctggcgggc aaggagctgt gcgccatgtc ggaggagcag ttccgccagc gctcgcccct gggtggggat gtgctgcacg cccacctgga catctggaag tcagcggcct ggatgaaaga gcggacttca cctggggcga ttcactactg tgcctcgacc agtgaggaga gctggaccga cagcgaggtg gactcatcat gctccgggca gcccatccac ctgtggcagt tcctcaagga gttgctactc aagccccaca gctatggccg cttcattagg tggctcaaca aggagaaggg catcttcaaa attgaggact cagcccaggt ggcccggctg tggggcatcc gcaagaaccg tcccgccatg aactacgaca agctgagccg ctccatccgc cagtattaca agaagggcat catccggaag ccagacatct cccagcgcct cgtctaccag ttcgtgcacc ccatctga
Molecular Weight
35,715 Da
OMIM
608144
Vector
pENTR223.1
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of SPDEF cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SPDEF. It may not necessarily be applicable to this product.

NCBI GI #
33878542
NCBI GeneID
25803
NCBI Accession #
BC021299
UniProt Secondary Accession #
B4DWH8; F5H778
UniProt Related Accession #
O95238
NCBI Official Full Name
Homo sapiens SAM pointed domain containing ets transcription factor, mRNA
NCBI Official Synonym Full Names
SAM pointed domain containing ETS transcription factor
NCBI Official Symbol
SPDEF
NCBI Official Synonym Symbols
PDEF; bA375E1.3
UniProt Protein Name
SAM pointed domain-containing Ets transcription factor
UniProt Synonym Protein Names
Prostate epithelium-specific Ets transcription factor; Prostate-specific Ets; Prostate-derived Ets factor
Protein Family
SAM pointed domain-containing Ets transcription factor
UniProt Gene Name
SPDEF
UniProt Synonym Gene Names
PDEF; PSE; Prostate-specific Ets
UniProt Entry Name
SPDEF_HUMAN
NCBI Protein Information
SAM pointed domain-containing Ets transcription factor

NCBI Summary for SPDEF

The protein encoded by this gene belongs to the ETS family of transcription factors. It is highly expressed in the prostate epithelial cells, and functions as an androgen-independent transactivator of prostate-specific antigen (PSA) promoter. Higher expression of this protein has also been reported in brain, breast, lung and ovarian tumors, compared to the corresponding normal tissues, and it shows better tumor-association than other cancer-associated molecules, making it a more suitable target for developing specific cancer therapies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
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UniProt Comments for SPDEF

SPDEF: May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT- 3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter. Belongs to the ETS family.

Protein type: Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: nucleus

Biological Process: cell differentiation; multicellular organismal development; negative regulation of transcription from RNA polymerase II promoter; positive regulation of apoptosis
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Research Articles on SPDEF

1. PDEF gene expression is associated with the extent of bladder neoplasia and PDEF modulated the expressions of EMT-related genes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with SPDEF cdna clone

 Products by Pathway  Pathway Diagram
 Regulation Of Androgen Receptor Activity Pathway antibodies  Regulation Of Androgen Receptor Activity Pathway Diagram

Diseases associated with SPDEF cdna clone

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >30 publications with SPDEF and Breast Neoplasms
 Prostatic Neoplasms Antibodies  >16 publications with SPDEF and Prostatic Neoplasms
 Prostatic Diseases Antibodies  >16 publications with SPDEF and Prostatic Diseases
 Neoplasm Metastasis Antibodies  >11 publications with SPDEF and Neoplasm Metastasis
 Adenocarcinoma Antibodies  >9 publications with SPDEF and Adenocarcinoma
 Metaplasia Antibodies  >8 publications with SPDEF and Metaplasia
 Hyperplasia Antibodies  >7 publications with SPDEF and Hyperplasia
 Ovarian Neoplasms Antibodies  >5 publications with SPDEF and Ovarian Neoplasms
 Fibrosis Antibodies  >4 publications with SPDEF and Fibrosis
 Thyroid Diseases Antibodies  >2 publications with SPDEF and Thyroid Diseases

Organs/Tissues associated with SPDEF cdna clone

 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >43 publications with SPDEF and Prostate
 Intestine Antibodies  >17 publications with SPDEF and Intestine
 Lung Antibodies  >16 publications with SPDEF and Lung
 Ovary Antibodies  >3 publications with SPDEF and Ovary
 Brain Antibodies  >2 publications with SPDEF and Brain
 Nerve Antibodies  >1 publications with SPDEF and Nerve
 Mammary Gland Antibodies  >1 publications with SPDEF and Mammary Gland
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