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JSH-150 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5759277

MBS5759277 is an inhibitor targeting JSH-150. JSH-150 is a highly selective CDK9 inhibitor(IC50 : 1nM). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
JSH-150, Inhibitor
Full Product Name
JSH-150
Product Gene Name
JSH-150, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
505.08
Solubility
DMSO: 16mg/mL (31.68mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C24H33ClN6O2S
SMILES
COCCN[C@H]1CC[C@@H](CC1)NC1=NC=C(Cl)C(=C1)C1=CSC(NCC2(CCOCC2)C#N)=N1
CAS Number
2247481-21-4
Target & IC50
CDK9/cyclinT1: ic50 1nM
CDK16/Cyclin Y: ic50 292nM
Cdk1/cyclin B: ic50 1.34uM
CDK14/Cyclin Y: ic50 1.68uM
CDK7/Cyclin H/MNAT1: ic50 1.72uM
cdk2/cyclin A: ic50 2.86uM
Cdk5/p25: ic50 4.64uM

Product Categories/Family for JSH-150, inhibitor

Cell Cycle/Checkpoint; CDK

Structure of JSH-150, inhibitor

JSH-150 Inhibitor – Cat# MBS5759277

Product References and Citations for JSH-150, inhibitor

Beilei Wang, et al. Discovery of 4-(((4-(5-chloro-2-(((1s,4s)-4-((2-methoxyethyl)amino)cyclohexyl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile (JSH-150) as a novel highly selective and potent CDK9 kinase inhibitor. Eur J Med Chem. 13 September 2018.

Other Notes

Small volumes of JSH-150, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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