P48645.1
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
Neuromedin-U
NCBI Official Synonym Full Names
neuromedin U
NCBI Protein Information
neuromedin-U; prepro-NMU
UniProt Protein Name
Neuromedin-U
UniProt Synonym Gene Names
UniProt Entry Name
NMU_HUMAN
NCBI Summary for NMU
This gene encodes a member of the neuromedin family of neuropeptides. The encoded protein is a precursor that is proteolytically processed to generate a biologically active neuropeptide that plays a role in pain, stress, immune-mediated inflammatory diseases and feeding regulation. Increased expression of this gene was observed in renal, pancreatic and lung cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. Some of these isoforms may undergo similar processing to generate the mature peptide. [provided by RefSeq, Jul 2015]
UniProt Comments for NMU
NMU: Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder. Belongs to the NmU family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 4q12
Cellular Component: extracellular region; terminal button
Molecular Function: neuromedin U receptor binding; receptor binding
Biological Process: regulation of smooth muscle contraction; gastric acid secretion; G-protein coupled receptor protein signaling pathway; neuropeptide signaling pathway; eating behavior; photoperiodism; digestion; positive regulation of hormone secretion; positive regulation of smooth muscle contraction; signal transduction; sensory perception of pain; positive regulation of synaptic transmission
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Products associated with anti-NMU antibody
Pathways associated with anti-NMU antibody
Diseases associated with anti-NMU antibody
Organs/Tissues associated with anti-NMU antibody
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