Veraguensin Inhibitor

Name: Veraguensin Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5759867
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5759867

Veraguensin shows activity against trypomastigote T. cruzi., it shows high antileishmanial activity. More details

Please Inquire

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Veraguensin, Inhibitor

Full Product Name

Veraguensin

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

372.45

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C22H28O5

SMILES

C[C@@H]([C@@H]1C)[C@H](c(cc2)cc(OC)c2OC)O[C@@H]1c(cc1)cc(OC)c1OC

CAS Number

19950-55-1

Target & IC50

NF-kappaB
p38
Antifection

In Vitro

The natural lignans grandisin (1) and Veraguensin (2) show activity against trypomastigote T. cruzi and their scaffold has been used as inspiration to design new derivatives with improved potency and chemical properties. We describe here the planning and microwave-irradiated synthesis of 26 isoxazole derivatives based on the structure of the lignans 1 and 2. In addition, the in vitro evaluation against culture trypomastigotes and intracellular amastigotes of T. cruzi and intracellular amastigotes of L. amazonensis and L. infantum is reported[1]

Product Categories/Family for Veraguensin, inhibitor

NF-kappab; NF-kappaB; MAPK; Microbiology&virology

Product References and Citations for Veraguensin, inhibitor

Design and synthesis of a new series of 3,5-disubstituted isoxazoles active against Trypanosoma cruzi and Leishmania amazonensis.Eur J Med Chem. 2017 Mar 10;128:25-35.
Design and synthesis of a new series of 3,5-disubstituted isoxazoles active against Trypanosoma cruzi and Leishmania amazonensis.Eur J Med Chem. 2017 Mar 10;128:25-35.
In vitro antileishmanial and antimalarial activities of tetrahydrofuran lignans isolated from Nectandra megapotamica (Lauraceae).Phytother Res. 2008 Oct;22(10):1307-10.

Other Notes

Small volumes of Veraguensin, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Veraguensin purchase

MBS5759867 is an inhibitor targeting Veraguensin.