Neocurdione Inhibitor

Name: Neocurdione Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5760699
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5760699

Neocurdione is an attachment inhibitor against the blue mussel, Mytilus edulis galloprovincialis. Neocurdione shows a protective effect against D-GalN/tumor necrosis factor-alpha-induced liver injury in mice at a dose of 50mg/kg p.o. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Neocurdione, Inhibitor

Full Product Name

Neocurdione

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

236.35

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C15H24O2

SMILES

CC(C)[C@@H](CC([C@@H](C)CC/C=C(\C)/C1)=O)C1=O

CAS Number

108944-67-8

Target & IC50

NO Synthase
TNF-alpha
Caspase

In Vitro

All isolated compounds except (3) were evaluated for their cytotoxic activity against MCF-7, Ca Ski, and HCT-116 cancer cell lines and noncancer human fibroblast cell line (MRC-5) using neutral red cytotoxicity assay. Curzerenone and alismol significantly inhibited cell proliferation in human cancer cell lines MCF-7, Ca Ski, and HCT-116 in a dose-dependent manner. Cytological observations by an inverted phase contrast microscope and Hoechst 33342/PI dual-staining assay showed typical apoptotic morphology of cancer cells upon treatment with curzerenone and alismol. Both compounds induce apoptosis through the activation of caspase-3.

Product Categories/Family for Neocurdione, inhibitor

Immunology/Inflammation; Apoptosis; Apoptosis

Product References and Citations for Neocurdione, inhibitor

In Vitro Morphological Assessment of Apoptosis Induced by Antiproliferative Constituents from the Rhizomes of Curcuma zedoaria.Evid Based Complement Alternat Med. 2013;2013:257108.

Other Notes

Small volumes of Neocurdione, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Neocurdione purchase

MBS5760699 is an inhibitor targeting Neocurdione.