Human CHAT cDNA Clone Expression Plasmid – Cat# MBS1272145

CHAT cDNA Clone – Choline Acetyltransferase (Human)

Name: CHAT cDNA Clone; Choline Acetyltransferase; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1272145
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1272145

MBS1272145 is a cDNA clone targeting CHAT. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CHAT, cDNA Clone

Full Product Name

CHAT cDNA Clone

Product Gene Name

CHAT cdna clone

Sequence

atggcagcaa aaactcccag cagtgaggag tctgggctgc ccaaactgcc cgtgcccccg ctgcagcaga ccctggccac gtacctgcag tgcatgcgac acttggtgtc tgaggagcag ttcaggaaga gccaggccat tgtgcagcag tttggggccc ctggtggcct cggcgagacc ctgcagcaga aactcctgga gcggcaggag aagacagcca actgggtgtc tgagtactgg ctgaatgaca tgtatctcaa caaccgcctg gccctgcctg tcaactccag ccctgccgtg atctttgctc ggcagcactt ccctggcacc gatgaccagc tgaggtttgc agccagcctc atctctggtg tactcagcta caaggccctg ctggacagcc actccattcc cactgactgt gccaaaggcc agctgtcagg gcagcccctt tgcatgaagc aatactatgg gctcttctcc tcctaccggc tccccggcca tacccaggac acgctggtgg ctcagaacag cagcatcatg ccggagcctg agcacgtcat cgtagcctgc tgcaatcagt tctttgtctt ggatgttgtc attaatttcc gccgtctcag tgagggggat ctgttcactc agttgagaaa gatagtcaaa atggcttcca acgaggacga gcgtttgcct ccaattggcc tgctgacgtc tgacgggagg agcgagtggg ccgaggccag gacggtcctc gtgaaagact ccaccaaccg ggactcgctg gacatgattg agcgctgcat ctgccttgta tgcctggacg cgccaggagg cgtggagctc agcgacaccc acagggcact ccagctcctt cacggcggag gctacagcaa gaacggggcc aatcgctggt acgacaagtc cctgcagttt gtggtgggcc gagacggcac ctgcggtgtg gtgtgcgaac actccccatt cgatggcatc gtcctggtgc agtgcactga gcatctgctc aagcacatga cgcagagcag caggaagctg atccgagcag actccgtcag cgagctcccc gccccccgga ggctgcggtg gaaatgctcc ccggaaattc aaggccactt agcctcctcg gcagaaaaac ttcaacgaat agtaaagaac cttgacttca ttgtctataa gtttgacaac tatgggaaaa cattcattaa gaagcagaaa tgcagccctg atgccttcat ccaggtggcc ctccagctgg ccttctacag gctccaccga agactggtgc ccacctacga gagcgcgtcc atccgccgat tccaggaggg acgcgtggac aacatcagat cggccactcc agaggcactg gcttttgtga gagccgtgac tgaccacaag gctgctgtgc cagcttctga gaagcttctg ctcctgaagg atgccatccg tgcccagact gcatacacag tcatggccat aacagggatg gccattgaca accacctgct ggcactgcgg gagctggccc gggccatgtg caaggagctg cccgagatgt tcatggatga aacctacctg atgagcaacc ggtttgtcct ctccactagc caggtgccca caaccacgga gatgttctgc tgctatggtc ctgtggtccc aaatgggtat ggtgcctgct acaaccccca gccagagacc atccttttct gcatctctag ctttcacagc tgcaaagaga cttcttctag caagtttgca aaagctgtgg aagaaagcct cattgacatg agagacctct gcagtctgct gccgcctact gagagcaagc cattggcaac aaaggaaaaa gccacgaggc ccagccaggg acaccaacct tga

Molecular Weight

70,394 Da

OMIM

118490

Vector

pENTR223.1

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of CHAT cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CHAT. It may not necessarily be applicable to this product.

NCBI GI #

123093961

NCBI GeneID

1103

NCBI Accession #

BC130615

UniProt Secondary Accession #

Q16488; Q9BQ23; Q9BQ35; Q9BQE1; A2BDF4; A2BDF5

UniProt Related Accession #

P28329

NCBI Official Full Name

Homo sapiens choline acetyltransferase, mRNA

NCBI Official Synonym Full Names

choline O-acetyltransferase

NCBI Official Symbol

CHAT

NCBI Official Synonym Symbols

CMS6; CMS1A; CMS1A2; CHOACTASE

UniProt Protein Name

Choline O-acetyltransferase

Protein Family

(Z)-3-hexen-1-ol acetyltransferase

UniProt Gene Name

CHAT

UniProt Synonym Gene Names

CHOACTase; ChAT; Choline acetylase

UniProt Entry Name

CLAT_HUMAN

NCBI Protein Information

choline O-acetyltransferase

NCBI Summary for CHAT

This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in this gene have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform. [provided by RefSeq, May 2010]

UniProt Comments for CHAT

CHAT: an enzyme that catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses. Four alternative splice variants have been described.

Protein type: Lipid Metabolism - glycerophospholipid; EC 2.3.1.6; Acetyltransferase

Chromosomal Location of Human Ortholog: 10q11.2

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: choline O-acetyltransferase activity

Biological Process: neurotransmitter secretion; phosphatidylcholine biosynthetic process

Disease: Myasthenic Syndrome, Congenital, Associated With Episodic Apnea

Research Articles on CHAT

1. sequence variants of CHAT were associated with human cognitive ability in not only patients with psychiatric disorders but also normal healthy individuals

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with CHAT cdna clone

Products by Pathway	Pathway Diagram
Acetylcholine Neurotransmitter Release Cycle Pathway antibodies	Acetylcholine Neurotransmitter Release Cycle Pathway Diagram
Acetylcholine Synthesis Pathway antibodies	Acetylcholine Synthesis Pathway Diagram
Biogenic Amine Synthesis Pathway antibodies	Biogenic Amine Synthesis Pathway Diagram
Cholinergic Synapse Pathway antibodies	Cholinergic Synapse Pathway Diagram
Glycerophospholipid Biosynthesis Pathway antibodies	Glycerophospholipid Biosynthesis Pathway Diagram
Glycerophospholipid Metabolism Pathway antibodies	Glycerophospholipid Metabolism Pathway Diagram
Glycerophospholipid Metabolism Pathway antibodies	Glycerophospholipid Metabolism Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Lipids And Lipoproteins Pathway antibodies	Metabolism Of Lipids And Lipoproteins Pathway Diagram
Neuronal System Pathway antibodies	Neuronal System Pathway Diagram

Diseases associated with CHAT cdna clone

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>1387 publications with CHAT and Nervous System Diseases
Neurobehavioral Manifestations Antibodies	>719 publications with CHAT and Neurobehavioral Manifestations
Brain Diseases Antibodies	>547 publications with CHAT and Brain Diseases
Dementia Antibodies	>356 publications with CHAT and Dementia
Alzheimer Disease Antibodies	>273 publications with CHAT and Alzheimer Disease
Drug Toxicity Antibodies	>242 publications with CHAT and Drug Toxicity
Disease Models, Animal Antibodies	>218 publications with CHAT and Disease Models, Animal
Nerve Degeneration Antibodies	>168 publications with CHAT and Nerve Degeneration
Memory Disorders Antibodies	>115 publications with CHAT and Memory Disorders
Learning Disorders Antibodies	>105 publications with CHAT and Learning Disorders

Organs/Tissues associated with CHAT cdna clone

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>2549 publications with CHAT and Brain
Eye Antibodies	>268 publications with CHAT and Eye
Testis Antibodies	>10 publications with CHAT and Testis