Orobol Inhibitor

Name: Orobol Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5760736
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5760736

Orobol is an inhibitor of tyrosine-specific protein kinase and phosphatidylinositol turnover, it has sensitization effect, it can produce produced cisplatin (DDP) sensitivity in human ovarian carcinoma cells by inducing apoptosis through the MT-dependent… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Orobol, Inhibitor

Full Product Name

Orobol

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

286.2

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C15H10O6

SMILES

Oc(cc1O)cc(OC=C2c(cc3)cc(O)c3O)c1C2=O

CAS Number

480-23-9

Target & IC50

PI3K
Caspase
Bcl-2

In Vitro

Isoflavonoid compounds, genistein, psi-tectorigenin and Orobol have been implicated as inhibitors of tyrosine-specific protein kinase and phosphatidylinositol turnover. These compounds have been frequently used as a pharmacological tool to assess signal transduction pathways in various cell systems. In the course of analyzing signaling pathways in rat hepatocytes, we obtained an unexpected finding that these compounds transiently increase cytoplasmic free calcium. Since the Ca2+ mobilizing effect was observed in 1microM calcium containing buffer, the source of the Ca2+ may be intracellular stores.

Product Categories/Family for Orobol, inhibitor

PI3K/Akt/mTOR signaling; PI3K; Apoptosis; Apoptosis

Product References and Citations for Orobol, inhibitor

Isoflavonoids, genistein, psi-tectorigenin, and orobol, increase cytoplasmic free calcium in isolated rat hepatocytes. Biochem Biophys Res Commun. 1992 Jan 31;182(2):894-9.

Other Notes

Small volumes of Orobol, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Orobol purchase

MBS5760736 is an inhibitor targeting Orobol.