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Tenacigenin B Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5760971

MBS5760971 is an inhibitor targeting Tenacigenin B. Standard reference More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Tenacigenin B, Inhibitor
Full Product Name
Tenacigenin B
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
364.5
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C21H32O5
SMILES
C[C@]([C@@H](CC1)C(C)=O)([C@@H]([C@H]2O)O)[C@@]11O[C@@]1(CC1)[C@H]2[C@@](C)(CC2)[C@@H]1C[C@H]2O
CAS Number
80508-42-5
Target & IC50
P-gp
In Vitro
Tenacissimoside A (1) and 11alpha-O-benzoyl-12beta- O-acetylTenacigenin B (2), two derivatives of Tenacigenin B (3) from the plant Marsdenia tenacissima, reversed multidrug resistance in P-glycoprotein (Pgp)-overexpressing multidrug-resistant cancer cells. The sensitivity of HepG2/Dox cells to the antitumor drugs doxorubicin, vinblastine, puromycin, and paclitexel was increased by 18-, 10-, 11-, and 6-fold by 20microg/mL (or 25microM) of 1 and 16-, 53-, 16-, and 326-fold by 20microg/mL (or 39microM) of 2, respectively[1]

Product Categories/Family for Tenacigenin B, inhibitor

Membrane transporter/Ion channel; P-gp

Product References and Citations for Tenacigenin B, inhibitor

Tenacigenin B derivatives reverse P-glycoprotein-mediated multidrug resistance inHepG2/Dox cells.J Nat Prod. 2008 Jun;71(6):1049-51.
Tenacigenin B derivatives reverse P-glycoprotein-mediated multidrug resistance inHepG2/Dox cells.J Nat Prod. 2008 Jun;71(6):1049-51.
The cytotoxic and tyrosine kinase inhibitory properties of C21 steroids and iridoids from the tubers of Alocasia cucullata.J Nat Med. 2016 Jul;70(3):602-9.

Other Notes

Small volumes of Tenacigenin B, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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