Coronarin D Inhibitor

Coronarin D shows promising antifungal activity against C. albicans in vitro, the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC) were 2 and 4mg/mL, respectively; it is active against tested Gram-positive bacteria, inactive for tested Gram-negative bacteria, and weakly active against tested fungi; using coronarin D-antibiotic drug combination can combat the infectious diseases.Coronarin D inhibits NF-kappaB activation pathway, which leads to inhibition of inflammation, invasion, and osteoclastogenesis, as well as potentiation of apoptosis.

Antimicrobial activity of coronarin D and its synergistic potential with antibiotics. Biomed Res Int. 2014;2014:581985.
Antifungal activity of coronarin D against Candida albicans. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Jul;114(1):61-6.

Small volumes of Coronarin D, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5762121 is an inhibitor targeting Coronarin D.