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HSD3B1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2530192

3 beta-hydroxysteroid dehydrogenase (3beta-HSD), also known as HSD3B1 or HSDB3, is a bifunctional enzyme that plays a crucial role in the synthesis of all classes of hormonal steroids. Two human 3beta-HSD proteins, designated type I (3beta-HSD) and type II… More details

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Product Overview

Online Datasheet in PDF
Product Name
HSD3B1, Polyclonal Antibody
Full Product Name
HSD3B1 Polyclonal Antibody
Product Gene Name
anti-HSD3B1 antibody
Product Synonym Names
I; HSD3B; HSDB3; HSDB3A; SDR11E1; 3BETAHSD
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Affinity purification
Concentration
2mg/mL (lot specific)
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
Molecular Weight
42kDa
OMIM
109715
3D Structure
ModBase 3D Structure for BC031999
Immunogen
Recombinant protein of human HSD3B1
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-HSD3B1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-HSD3B1 antibody
WB: 1:200-1:1000
IHC: 1:50-1:200

Western Blot (WB) of anti-HSD3B1 antibody

Western Blot analysis of Human adrenal gland tissue using HSD3B1 Polyclonal Antibody at dilution of 1:250
Rabbit Anti-HSD3B1 Polyclonal Antibody – Cat# MBS2530192

Immunohistochemistry (IHC) of anti-HSD3B1 antibody

Immunohistochemistry of paraffin-embedded Human thyroid cancer using HSD3B1 Polyclonal Antibody at dilution of 1:40
Rabbit Anti-HSD3B1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2530192

Immunohistochemistry (IHC) of anti-HSD3B1 antibody

Immunohistochemistry of paraffin-embedded Human brain using HSD3B1 Polyclonal Antibody at dilution of 1:40
Rabbit Anti-HSD3B1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2530192

Other Notes

Small volumes of anti-HSD3B1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HSD3B1 purchase

MBS2530192 is an antibody targeting HSD3B1. Also known as HSD3B1 Polyclonal Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for HSD3B1. It may not necessarily be applicable to this product.

NCBI GI #
21619294
NCBI GeneID
3283
NCBI Accession #
AAH31999.1
UniProt Primary Accession #
BC031999
UniProt Secondary Accession #
Q14545; Q8IV65; A8K691
UniProt Related Accession #
P14060
NCBI Official Full Name
Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
NCBI Official Synonym Full Names
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
NCBI Official Symbol
HSD3B1
NCBI Official Synonym Symbols
I; HSD3B; HSDB3; HSDB3A; SDR11E1; 3BETAHSD
UniProt Protein Name
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
UniProt Synonym Protein Names
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I; 3-beta-HSD I; Trophoblast antigen FDO161GIncluding the following 2 domains:3-beta-hydroxy-Delta(5)-steroid dehydrogenase (EC:1.1.1.145)Alternative name(s):3-beta-hydroxy-5-ene steroid dehydrogenase; Progesterone reductase
Protein Family
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase
UniProt Gene Name
HSD3B1
UniProt Synonym Gene Names
3BH; HSDB3A; 3-beta-HSD I
UniProt Entry Name
3BHS1_HUMAN
NCBI Protein Information
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I; 3-beta-HSD I; 3-beta-hydroxy-5-ene steroid dehydrogenase; 3-beta-hydroxy-Delta(5)-steroid dehydrogenase; delta-5-3-ketosteroid isomerase; hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 1; progesterone reductase; short chain dehydrogenase/reductase family 11E, member 1; steroid Delta-isomerase; trophoblast antigen FDO161G

UniProt Comments for HSD3B1

HSD3B1: 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. Efficiently catalyzes the transformation of pregnenolone to progesterone, 17-alpha-hydroxypregnenolone to 17- alpha-hydroxyprogesterone, DHEA to 4-androstenedione, dihydrotestosterone to 5-alpha-androstane-3 beta,17 beta-diol, dehydroepiandrosterone to androstenedione and 5-alpha-androstan-3 beta,17 beta-diol to 5-alpha-dihydrotestosterone. Belongs to the 3-beta-HSD family.

Protein type: Isomerase; Lipid Metabolism - androgen and estrogen; Oxidoreductase; Membrane protein, integral; Lipid Metabolism - C21-steroid hormone; Mitochondrial; EC 1.1.1.145; EC 5.3.3.1

Chromosomal Location of Human Ortholog: 1p13.1

Cellular Component: endoplasmic reticulum membrane; mitochondrial inner membrane; integral to membrane; mitochondrial intermembrane space; smooth endoplasmic reticulum membrane

Molecular Function: steroid delta-isomerase activity; 3-beta-hydroxy-delta5-steroid dehydrogenase activity

Biological Process: steroid metabolic process; mineralocorticoid biosynthetic process; androgen biosynthetic process; glucocorticoid biosynthetic process; estrogen biosynthetic process; steroid biosynthetic process
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Research Articles on HSD3B1

1. The AngII-NGFIB/NURR1 pathway controls HSD3B1 expression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-HSD3B1 antibody

 Reference Product  PubMed Publications
 CYP11A1 antibody  >64 publications with HSD3B1 and CYP11A1
 CYP17A1 antibody  >51 publications with HSD3B1 and CYP17A1
 CYP19A1 antibody  >44 publications with HSD3B1 and CYP19A1
 HSD17B2 antibody  >19 publications with HSD3B1 and HSD17B2
 HSD17B3 antibody  >15 publications with HSD3B1 and HSD17B3
 SRD5A2 antibody  >14 publications with HSD3B1 and SRD5A2
 CYP3A5 antibody  >1 publications with HSD3B1 and CYP3A5
 HSD17B6 antibody  >1 publications with HSD3B1 and HSD17B6

Pathways associated with anti-HSD3B1 antibody

 Products by Pathway  Pathway Diagram
 Androgen Biosynthesis Pathway antibodies  Androgen Biosynthesis Pathway Diagram
 C19/C18-Steroid Hormone Biosynthesis, Pregnenolone => Androstenedione => Estrone Pathway antibodies  C19/C18-Steroid Hormone Biosynthesis, Pregnenolone => Androstenedione => Estrone Pathway Diagram
 C19/C18-Steroid Hormone Biosynthesis, Pregnenolone => Androstenedione => Estrone Pathway antibodies  C19/C18-Steroid Hormone Biosynthesis, Pregnenolone => Androstenedione => Estrone Pathway Diagram
 Corticotropin-releasing Hormone Pathway antibodies  Corticotropin-releasing Hormone Pathway Diagram
 Glucocorticoid & Mineralcorticoid Metabolism Pathway antibodies  Glucocorticoid & Mineralcorticoid Metabolism Pathway Diagram
 Glucocorticoid Biosynthesis Pathway antibodies  Glucocorticoid Biosynthesis Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Metabolism Of Steroid Hormones And Vitamin D Pathway antibodies  Metabolism Of Steroid Hormones And Vitamin D Pathway Diagram

Diseases associated with anti-HSD3B1 antibody

 Disease Name  Pubmed Publications
 Hypertension Antibodies  >12 publications with HSD3B1 and Hypertension
 Hyperplasia Antibodies  >11 publications with HSD3B1 and Hyperplasia
 Prostatic Neoplasms Antibodies  >10 publications with HSD3B1 and Prostatic Neoplasms
 Cardiovascular Diseases Antibodies  >9 publications with HSD3B1 and Cardiovascular Diseases
 Necrosis Antibodies  >4 publications with HSD3B1 and Necrosis
 Infertility, Female Antibodies  >4 publications with HSD3B1 and Infertility, Female
 Ovarian Diseases Antibodies  >4 publications with HSD3B1 and Ovarian Diseases
 Hypertrophy Antibodies  >3 publications with HSD3B1 and Hypertrophy
 Neoplasms, Experimental Antibodies  >3 publications with HSD3B1 and Neoplasms, Experimental
 Liver Neoplasms Antibodies  >2 publications with HSD3B1 and Liver Neoplasms

Organs/Tissues associated with anti-HSD3B1 antibody

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >34 publications with HSD3B1 and Testis
 Blood Antibodies  >31 publications with HSD3B1 and Blood
 Placenta Antibodies  >19 publications with HSD3B1 and Placenta
 Embryonic Tissue Antibodies  >10 publications with HSD3B1 and Embryonic Tissue
 Uterus Antibodies  >8 publications with HSD3B1 and Uterus
 Heart Antibodies  >4 publications with HSD3B1 and Heart
 Skin Antibodies  >1 publications with HSD3B1 and Skin
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