Hirsutanonol Inhibitor

Hirsutanonol has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid peroxidation. Hirsutanonol shows potent cytotoxic activities against murine B16 melanoma cells and human SNU-C1 gastric cancer cells, it also has chemoprotective effect on human lymphocytes DNA. Hirsutanonol or oregonin as an active ingredient composition for treating atopic dermatitis, hirsutanonol shows significant inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cyclooxygenase-2 (COX-2) expression in immortalized human breast epithelial MCF10A cells. Hirustenone and hirsutanonol show promising anti-filarial activity both in vitro and in vivo studies.

Diarylheptanoids from Alnus glutinosa bark and their chemoprotective effect on human lymphocytes DNA. Planta Med. 2013 Apr;79(6):499-505.
Cytotoxic activities of diarylheptanoids from Alnus japonica. Arch Pharm Res. 2008 Oct;31(10):1287-9.
Constituents and their DPPH Scavenging Activities from the Leaves of Alnus hirsuta (Spach) Rupr. Korean J. Medicinal Crop Sci.,2005,13(2):85-90.

Small volumes of Hirsutanonol, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5762520 is an inhibitor targeting Hirsutanonol.