CD34 Antibody – Rat Monoclonal

CD34: Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins. Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues. Belongs to the CD34 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cell surface

Cellular Component: intercellular bridge; cell surface; membrane; perinuclear region of cytoplasm; lysosome; cytoplasm; apical plasma membrane; basal plasma membrane; plasma membrane; extracellular region; integral to membrane; external side of plasma membrane

Molecular Function: sulfate binding; carbohydrate binding; transcription factor binding

Biological Process: positive regulation of odontogenesis; negative regulation of nitric oxide biosynthetic process; negative regulation of blood coagulation; negative regulation of tumor necrosis factor production; positive regulation of interleukin-10 production; positive regulation of angiogenesis; cell-cell adhesion; regulation of blood pressure; endothelial cell proliferation; tissue homeostasis; hemopoiesis; cell adhesion; leukocyte migration