Shizukaol B Inhibitor

Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinflammatory effects by inhibiting nitric-oxide (NO) production in lipopolysaccharide (LPS)-stimulated murine BV-2 microglial cells with relatively low cytotoxicity. Shizukaol B exhibits anti-HIV-1 replication activities in both wild-type HIV-1 and two NNRTIs-resistant strains, it also has significant cytotoxicities against C8166 cells. Shizukaol B prevents monocyte adhesion to HUVEC through the inhibition of cell adhesion molecules expression stimulated by TNF-alpha.

Shizukaol B, an active sesquiterpene from Chloranthus henryi, attenuates LPS-induced inflammatory responses in BV2 microglial cells. Biomed Pharmacother. 2017 Apr;88:878-884
Sesquiterpenoids from Chloranthus henryi and their anti-neuroinflammatory activities. Chem Biodivers. 2014 Jun;11(6):919-28.
Lindenane disesquiterpenoids with anti-HIV-1 activity from Chloranthus japonicus. J Nat Prod. 2011 Jun 24;74(6):1408-13

Small volumes of Shizukaol B, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5763112 is an inhibitor targeting Shizukaol B.