PKC Inhibitor – Beta Pseudosubstrate

Selective cell-permeable peptide inhibitor of protein kinase C (IC50 ~ 0.5uM). Consists of amino acids 19 - 31 of PKC pseudosubstrate domain linked by a disulphide bridge to a cell permeabilisation Antennapedia domain vector peptide. The Antennapedia peptide is actively taken up by intact cells, at 4 or 37 degree C, ensuring rapid and effective uptake of the inhibitor peptide. Once inside the cell, the disulphide bonds are subjected to reduction in the cytoplasm leading to release of the inhibitor peptide.

Derossi et al (1994) The third helix of the antennapedia homeodomain translocates through biological membranes. J. Biol.Chem. 269 10444 PMID:
Derossi et al (1994) The third helix of the antennapedia homeodomain translocates through biological membranes. J. Biol.Chem. 269 10444 PMID:
House and Kemp (1987) Protein kinase C contains a pseudosubstrate prototope in its regulatory domain. Science 238 1726 PMID:
House and Kemp (1987) Protein kinase C contains a pseudosubstrate prototope in its regulatory domain. Science 238 1726 PMID:
Theodore et al (1995) Intraneuronal delivery of protein kinase C pseudosubstrate leads to growth cone collapse. J.Neurosci. 15 7158 PMID:
Theodore et al (1995) Intraneuronal delivery of protein kinase C pseudosubstrate leads to growth cone collapse. J.Neurosci. 15 7158 PMID:

Small volumes of PKC, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5763953 is an inhibitor targeting PKC. Also known as PKC beta pseudosubstrate.