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IGHM Inhibitor – Immunoglobulin M Heavy Chain () Fragment

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5764221

Immunoglobulin M heavy chain (IGHM) fragment [Homo sapiens] is a fragment (Gly-Val-Ala-Leu-His-Arg-Pro-Asp-Val-Tyr-Leu-Leu-Pro-Pro-Ala-Arg) on the human immunoglobulin micro heavy chain. Immunoglobulins (Ig) are the antigen recognition molecules of B cells.… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Immunoglobulin M heavy chain (IGHM) fragment, Inhibitor
Full Product Name
Immunoglobulin M heavy chain (IGHM) fragment [Homo sapiens]
Product Gene Name
IGHM, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
1774.07
Solubility
DMSO: >=177.4mg/mL
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C82H132N24O20
SMILES
O=C(N[C@]([H])(C(=O)N[C@](C)([H])C(=O)N[C@@]([H])(CC(C)(C)[H])C(=O)N[C@@]([H])(C/C1=C/NC=N1)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N2CCC[C@]2([H])C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@]([H])(C(=O)N[C@@]([H])(C/C3=C/C=C(/O)C=C3)C(=O)N[C@@]([H])(CC(C)(C)[H])C(=O)N[C@@]([H])(CC(C)(C)[H])C(=O)N4CCC[C@]4([H])C(=O)N5CCC[C@]5([H])C(=O)N[C@](C)([H])C(=O)N[C@]([H])(CCCNC(N)=N)C(O)=O)C(C)(C)[H])C(C)(C)[H])CN
In Vitro
The IGHM gene encodes the C region of the mu heavy chain, which defines the IgM isotype. Naive B cells express the transmembrane forms of IgM and IgD on their surface. During an antibody response, activated B cells can switch to the expression of individual downstream heavy chain C region genes by a process of somatic recombination known as isotype switching. In addition, secreted Ig forms that act as antibodies can be produced by alternative RNA processing of the heavy chain C region sequences. Although the membrane forms of all Ig isotypes are monomeric, secreted IgM forms pentamers, and occasionally hexamers, in plasma.

Other Notes

Small volumes of IGHM, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IGHM purchase

MBS5764221 is an inhibitor targeting IGHM. Also known as Immunoglobulin M heavy chain (IGHM) fragment [Homo sapiens].
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