BAY-1436032 Inhibitor

Name: BAY-1436032 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5764300
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5764300

BAY-1436032 is a novel, selective and orally available inhibitor of pan-mutant isocitrate dehydrogenase 1 (IDH1). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

BAY-1436032, Inhibitor

Full Product Name

BAY-1436032

Product Gene Name

BAY-1436032, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

489.53

Solubility

DMSO: 120mg/mL (245.14mM) Need ultrasonic and warming
Water: Insoluble
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C26H29F3N3O3

SMILES

O=C(O)CCC1=CC=C2C(N=C(NC3=CC=C(OC(F)(F)F)C=C3)N2[C@]4CC(C)(C)C[C@@H](C)C4)=C1

CAS Number

1803274-65-8

Cell Research

Colony-forming cell (CFC) units are assayed in methylcellulose supplemented with 10ng/mL IL-3, 10ng/mL GM-CSF, 50ng/mL SCF, 50ng/mL FLT3-ligand and 3U/mL EPO. Vehicle or BAY-1436032 is added to methylcellulose containing 1 x 10^5 human mononuclear cells, which are plated in duplicate. Colonies are evaluated microscopically 10 to 14 days after plating by standard criteria.

Product Categories/Family for BAY-1436032, inhibitor

Metabolism; Dehydrogenase

Product References and Citations for BAY-1436032, inhibitor

Chaturvedi A, et al. Pan-mutant-IDH1 inhibitor BAY1436032 is highly effective against human IDH1 mutant acute myeloid leukemia in vivo. Leukemia. 2017 Oct;31(10):2020-2028.

Other Notes

Small volumes of BAY-1436032, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BAY-1436032 purchase

MBS5764300 is an inhibitor targeting BAY-1436032.