JPH203 Inhibitor

Name: JPH203 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5764338
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5764338

JPH203 is an effective and specific L-type amino acid transporter 1 (LAT-1) inhibitor. More details

Please Inquire

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

JPH203, Inhibitor

Full Product Name

JPH203

Product Gene Name

JPH203, inhibitor

Product Synonym Names

KYT-0353

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

472.32

Solubility

0.1N hydrochloric acid: 7mg/mL (14.82mM) Need ultrasonic and warming
Methanol: 6mg/mL (12.7mM) Need ultrasonic
DMSO: Insoluble or Slightly soluble
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C23H19Cl2N3O4

SMILES

N[C@@H](Cc(cc1Cl)cc(Cl)c1OCc1c2oc(-c3ccccc3)nc2cc(N)c1)C(O)=O

CAS Number

1037592-40-7

Cell Research

Growth inhibition is evaluated by the MTT assay method. Namely, cell suspensions (1 x 10^4 cells/mL) in a volume of 135 uL are placed into the wells of a flat-bottom 96-well microtiter plate and incubated in the atmosphere of 5% CO2 at 37 degree C (24 h). Drug solutions (15uL) at various concentrations are added and incubated (96 h) under the same conditions. Next, MTT (15uL, 5mg/mL) dissolved in PBS is added and incubated (4.0 h). The incubation medium containing MTT is aspirated off. Cells are mixed (5 minutes) with DMSO (200uL) and optical density read (540nM) using a microtiter plate reader Emax. Subsequently, IC50 values are determined [1].

In Vitro

JPH203 (6.3, 12.5, and 25.0mg/kg, i.v. for 14 days) has dose-dependent inhibition on HT-29 tumor growth in nude mice [1].

Product Categories/Family for JPH203, inhibitor

Autophagy; Autophagy

Product References and Citations for JPH203, inhibitor

Oda K, et al. L-type amino acid transporter 1 inhibitors inhibit tumor cell growth. Cancer Sci. 2010 Jan;101(1):173-9.
Oda K, et al. L-type amino acid transporter 1 inhibitors inhibit tumor cell growth. Cancer Sci. 2010 Jan;101(1):173-9.
Yun DW, et al. JPH203, an L-type amino acid transporter 1-selective compound, induces apoptosis of YD-38 human oral cancer cells. J Pharmacol Sci. 2014;124(2):208-17. Epub 2014 Feb 4.
Yun DW, et al. JPH203, an L-type amino acid transporter 1-selective compound, induces apoptosis of YD-38 human oral cancer cells. J Pharmacol Sci. 2014;124(2):208-17. Epub 2014 Feb 4.
Choi DW, et al. JPH203, a selective L-type amino acid transporter 1 inhibitor, induces mitochondria-dependent apoptosis in Saos2 human osteosarcoma cells. Korean J Physiol Pharmacol. 2017 Nov;21(6):599-607.
Choi DW, et al. JPH203, a selective L-type amino acid transporter 1 inhibitor, induces mitochondria-dependent apoptosis in Saos2 human osteosarcoma cells. Korean J Physiol Pharmacol. 2017 Nov;21(6):599-607.

Other Notes

Small volumes of JPH203, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for JPH203 purchase

MBS5764338 is an inhibitor targeting JPH203.