Inulicin Inhibitor

Name: Inulicin Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5764425
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5764425

Inulicin, an active compound isolated from Inula Britannica L., inhibits VEGF-mediated activation of Src and FAK. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Inulicin, Inhibitor

Full Product Name

Inulicin

Product Synonym Names

1-O-Acetylbritannilactone

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

308.37

Solubility

Ethanol: 45mg/mL (145.93mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C17H24O5

SMILES

C[C@@H](CCCOC(C)=O)C([C@H]([C@@H]1C2=C)O)=C(C)C[C@H]1OC2=O

CAS Number

33627-41-7

Cell Research

HUVECs or A549 cells are plated in 60mM plates (300 cells/plate). After overnight incubation, cells are treated with applied agents (Inulicin; 5uM and 10uM) for 24 hours. Cells are then washed, and fresh media are added. After 10 days of incubation, surviving colonies are fixed, stained, and manually counted [1].

In Vitro

Administration of a single dose of Inulicin (12mg/kg/day) remarkably suppresses the growth of A549 xenografts in nude mice. In vivo, microvessels formation and Src activation are also significantly inhibited in Inulicin-treated xenograft tumors. A single dose of Inulicin (12mg/kg/day, i.p.) dramatically inhibits the growth of A549 xenografts in nude mice. Further, the weights of Inulicin-treated tumors are remarkably lighter than that of vehicle-treated tumors [1].

Product Categories/Family for Inulicin, inhibitor

Angiogenesis; Src; NF-kappab; Immunology/Inflammation

Product References and Citations for Inulicin, inhibitor

Zhengfu H, et al. 1-o-acetylbritannilactone (ABL) inhibits angiogenesis and lung cancer cell growth through regulating VEGF-Src-FAK signaling. Biochem Biophys Res Commun. 2015 Aug 21;464(2):422-7.
Zhengfu H, et al. 1-o-acetylbritannilactone (ABL) inhibits angiogenesis and lung cancer cell growth through regulating VEGF-Src-FAK signaling. Biochem Biophys Res Commun. 2015 Aug 21;464(2):422-7.
Liu YP, et al. Acetylbritannilactone suppresses lipopolysaccharide-induced vascular smooth muscle cell inflammatory response. Eur J Pharmacol. 2007 Dec 22;577(1-3):28-34.
Liu YP, et al. Acetylbritannilactone suppresses lipopolysaccharide-induced vascular smooth muscle cell inflammatory response. Eur J Pharmacol. 2007 Dec 22;577(1-3):28-34.

Other Notes

Small volumes of Inulicin, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Inulicin purchase

MBS5764425 is an inhibitor targeting Inulicin.