Collagen II Antibody – Mouse Monoclonal

Product Description: The monoclonal antibody M2139 reacts with the J1 epitope (triple helical position 551-564) of collagen type II. Collagen is a structural protein in bone, cartillage and connective tissue. Collagen type II (CII) is the major collagen of the nucleus pulposa (a component of spine), cartilage and vitreous (a component of the eye). The most commonly used animal model for rheumatoid arthritis (RA) is the collagen-induced arthritis (CIA). Transfer of collagen type II specific monoclonal antibodies induces an acute form of arthritis (collagen type II antibody induced arthritis, CAIA). The monocolonal antibody M2139 has been shown to induce CAIA in na¯ve mice after injection of lipopolysacharide (LPS). However, in combination with the monoclonal antibody CIIC1, binding to the C1 epitope of CII, the pair of monoclonal antibodies induce arthritis in different strains of mice without any other stimulants. The presence of secondary stimulus, LPS, increases the disease incidence and severity. The monoclonal antibody M2139 is cross reactive with rat, bovine, chicken and human CII.

1. Nandakumar, K et al; Collagen Type II-specific monoclonal antibody-induced arthritis in mice. Description of the disease and the influence of age, sex and genes. Am J Pathol 2003, 163: 1827 2. Nandakumar, K et al; Collagen type II (CII)-specific antibodies induce arthritis in the absence of T or B cells but the arthritis progression is enhanced by CII-reactive T cells. Arthritis Res Ther 2004, 6: R544

Small volumes of anti-Collagen II antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS584241 is an antibody targeting Collagen II. Also known as Collagen II, Mouse, mAb M2139. Reactive in Reactivity: Mouse. Cross reactivity: Bovine, Chicken, Human, Rat. Host: Mouse.