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ADP Ribosylation Factor 6 (ARF6) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS588262

The ARF subfamily comprises a group of proteins that are members of the Ras superfamily of small guanosine triphosphatases (small GTPases). Six ARFs have been identified by related gene products from different species. These 6 members can be divided into… More details

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Product Overview

Product Name
ADP Ribosylation Factor 6 (Arf6), Polyclonal Antibody
Full Product Name
ADP Ribosylation Factor 6 (Arf6) Rabbit Polyclonal Antibody
Product Gene Name
anti-Arf6 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Lyophilized serum
Specificity
The antibody recognizes the human human ADP ribosylation factor 6 (Arf6) protein.
Preparation and Storage
Lyophilized antibody can be kept at 4 degree C for up to 3 months and should be kept at-20 degree C for long-term storage.
To avoid freeze-thaw cycles, reconstituted antibody should be aliquoted before freezing for short-term storage (-20 degree C) or for long-term storage (-80 degree C).
For maximum recovery of product centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
20,082 Da
3D Structure
ModBase 3D Structure for P62330
Applications Tested/Suitable for anti-Arf6 antibody
Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-Arf6 antibody
If reconstituted in 100 muL: WB: 1:2000; IHC: 1:100-1:250.

Product References and Citations for anti-Arf6 antibody

1. Marshansky V-Identification of ADP-ribosylation factor-6 in brush-border membrane and early endosomes of human kidney proximal tubules.

Other Notes

Small volumes of anti-Arf6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Arf6 purchase

MBS588262 is an antibody targeting Arf6. Also known as ADP Ribosylation Factor 6 (Arf6) Rabbit Polyclonal Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Arf6. It may not necessarily be applicable to this product.

NCBI GI #
4502211
NCBI GeneID
382
NCBI Accession #
NP_001654.1
UniProt Primary Accession #
P62330
UniProt Secondary Accession #
P26438; Q6FGZ2
UniProt Related Accession #
P62330
GenBank Nucleotide #
NM_001663.4
NCBI Official Full Name
ADP-ribosylation factor 6
NCBI Official Synonym Full Names
ADP ribosylation factor 6
NCBI Official Symbol
ARF6
UniProt Protein Name
ADP-ribosylation factor 6
Protein Family
ADP-ribosylation factor
UniProt Gene Name
ARF6
NCBI Protein Information
ADP-ribosylation factor 6

NCBI Summary for Arf6

This gene encodes a member of the human ARF gene family, which is part of the RAS superfamily. The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The product of this gene is localized to the plasma membrane, and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling. A pseudogene of this gene is located on chromosome 7. [provided by RefSeq, Jul 2008]
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UniProt Comments for Arf6

GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling (PubMed:11266366, PubMed:21170023, PubMed:16737952, PubMed:7589240, PubMed:18400762). Required for normal completion of mitotic cytokinesis (). Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers (). Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension (PubMed:14978216). Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization. Regulates surface levels of adherens junction proteins such as CDH1 (). Required for NTRK1 sorting to the recycling pathway from early endosomes ().
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Research Articles on Arf6

1. Data show that the ADP-ribosylation factor 6 (Arf6)-trafficking kinesin protein 1 (trak1) promote the anterograde trafficking of mitochondria.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Arf6 antibody

 Reference Product  PubMed Publications
 PLD1 antibody  >21 publications with Arf6 and PLD1
 ASAP3 antibody  >4 publications with Arf6 and ASAP3
 ASAP2 antibody  >4 publications with Arf6 and ASAP2
 CYTH2 antibody  >3 publications with Arf6 and CYTH2
 ARFIP2 antibody  >3 publications with Arf6 and ARFIP2
 RAB11FIP3 antibody  >1 publications with Arf6 and RAB11FIP3
 AP3B1 antibody  >1 publications with Arf6 and AP3B1

Pathways associated with anti-Arf6 antibody

 Products by Pathway  Pathway Diagram
 Arf6 Downstream Pathway antibodies  Arf6 Downstream Pathway Diagram
 Arf6 Signaling Events Pathway antibodies  Arf6 Signaling Events Pathway Diagram
 Arf6 Trafficking Events Pathway antibodies  Arf6 Trafficking Events Pathway Diagram
 Class I PI3K Signaling Events Pathway antibodies  Class I PI3K Signaling Events Pathway Diagram
 E-cadherin Signaling In The Nascent Adherens Junction Pathway antibodies  E-cadherin Signaling In The Nascent Adherens Junction Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram

Diseases associated with anti-Arf6 antibody

 Disease Name  Pubmed Publications
 Neoplasm Metastasis Antibodies  >13 publications with Arf6 and Neoplasm Metastasis
 Lung Neoplasms Antibodies  >6 publications with Arf6 and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >5 publications with Arf6 and Neoplasms, Experimental
 Cell Transformation, Neoplastic Antibodies  >5 publications with Arf6 and Cell Transformation, Neoplastic
 Inflammation Antibodies  >5 publications with Arf6 and Inflammation
 Disease Models, Animal Antibodies  >4 publications with Arf6 and Disease Models, Animal
 Drug Toxicity Antibodies  >3 publications with Arf6 and Drug Toxicity
 Carcinoma, Hepatocellular Antibodies  >3 publications with Arf6 and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >3 publications with Arf6 and Liver Diseases
 Embryo Loss Antibodies  >3 publications with Arf6 and Embryo Loss

Organs/Tissues associated with anti-Arf6 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >62 publications with Arf6 and Blood
 Brain Antibodies  >57 publications with Arf6 and Brain
 Lung Antibodies  >28 publications with Arf6 and Lung
 Heart Antibodies  >25 publications with Arf6 and Heart
 Muscle Antibodies  >23 publications with Arf6 and Muscle
 Liver Antibodies  >11 publications with Arf6 and Liver
 Connective Tissue Antibodies  >5 publications with Arf6 and Connective Tissue
 Eye Antibodies  >5 publications with Arf6 and Eye
 Pancreas Antibodies  >5 publications with Arf6 and Pancreas
 Ear Antibodies  >4 publications with Arf6 and Ear
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