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FOSB Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS600155

The v-Fos oncogene was initially identified as the transforming gene of two independent murine osteosarcoma virus isolates (1,2) and an avian nephroblastoma virus (3). The cellular homolog, c-Fos, encodes a 62kD nuclear phosphoprotein that is rapidly and… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
FosB, Monoclonal Antibody
Full Product Name
FosB
Product Gene Name
anti-FOSB antibody
Product Synonym Names
Anti -FosB
Clonality
Monoclonal
Isotype
IgG1
Clone Number
4H90
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.02% sodium azide, before the addition of glycerol to 40%.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human FosB.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
35,995 Da
Chromosome Location
Chromosome: 19; NC_000019.9 (45971253..45978437). Location: 19q13.32
OMIM
164772. gene.
3D Structure
ModBase 3D Structure for Q6FGK6
Immunogen
Synthetic peptide corresponding to aa2-15 of human FosB.
Positive Control
HeLa cells

Product Categories/Family for anti-FOSB antibody

Antibodies; Abs to Proteins
Applications Tested/Suitable for anti-FOSB antibody
Western Blot (WB)
Application Notes for anti-FOSB antibody
Suitable for use in Western Blot.
Dilution: Western Blot: 2ug/ml; Band at 46kD.

Western Blot (WB) of anti-FOSB antibody

Western blot analysis of FosB in HeLa cell lysate with MBS600155. A protein band of approximate molecular weight of 46 kD is detected.
Mouse Anti-FOSB Monoclonal Antibody – Cat# MBS600155

Other Notes

Small volumes of anti-FOSB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FOSB purchase

MBS600155 is an antibody targeting FOSB. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for FOSB. It may not necessarily be applicable to this product.

NCBI GI #
49457155
NCBI GeneID
2354
UniProt Primary Accession #
Q6FGK6
UniProt Secondary Accession #
A8K9K5
UniProt Related Accession #
P53539; Q49AD7; Q6FGK6
NCBI Official Full Name
FOSB
NCBI Official Synonym Full Names
FBJ murine osteosarcoma viral oncogene homolog B
NCBI Official Symbol
FOSB
NCBI Official Synonym Symbols
AP-1; G0S3; GOS3; GOSB; MGC42291; DKFZp686C0818
UniProt Protein Name
FOSB protein
UniProt Synonym Protein Names
G0/G1 switch regulatory protein 3
Protein Family
Metallothiol transferase
UniProt Gene Name
FOSB
UniProt Synonym Gene Names
G0S3
UniProt Entry Name
Q6FGK6_HUMAN
NCBI Protein Information
protein fosB; oncogene FOS-B; activator protein 1; G0/G1 switch regulatory protein 3

NCBI Summary for FOSB

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
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UniProt Comments for FOSB

FosB: FosB interacts with Jun proteins enhancing their DNA binding activity. Heterodimer. Belongs to the bZIP family. Fos subfamily.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 19q13.32

Cellular Component: nucleus

Molecular Function: DNA binding; sequence-specific DNA binding; double-stranded DNA binding; transcription factor activity; transcription factor binding

Biological Process: transcription from RNA polymerase II promoter; response to drug; response to cAMP; response to mechanical stimulus; response to morphine; negative regulation of transcription from RNA polymerase II promoter; female pregnancy; response to progesterone stimulus; cellular response to hormone stimulus; response to corticosterone stimulus
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Research Articles on FOSB

1. Findings indicate that neurobehavioral stress leads to FosB-driven increases in IL8, which is associated with increased tumor growth and metastases.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FOSB antibody

 Reference Product  PubMed Publications
 JUNB antibody  >186 publications with FOSB and JUNB
 JUND antibody  >156 publications with FOSB and JUND

Pathways associated with anti-FOSB antibody

 Products by Pathway  Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 TGF-beta Receptor Signaling Pathway antibodies  TGF-beta Receptor Signaling Pathway Diagram

Diseases associated with anti-FOSB antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >70 publications with FOSB and Nervous System Diseases
 Substance-Related Disorders Antibodies  >68 publications with FOSB and Substance-Related Disorders
 Mental Disorders Antibodies  >55 publications with FOSB and Mental Disorders
 Disease Models, Animal Antibodies  >55 publications with FOSB and Disease Models, Animal
 Brain Diseases Antibodies  >55 publications with FOSB and Brain Diseases
 Drug Toxicity Antibodies  >49 publications with FOSB and Drug Toxicity
 Movement Disorders Antibodies  >38 publications with FOSB and Movement Disorders
 Dyskinesias Antibodies  >32 publications with FOSB and Dyskinesias
 Parkinsonian Disorders Antibodies  >30 publications with FOSB and Parkinsonian Disorders
 Basal Ganglia Diseases Antibodies  >30 publications with FOSB and Basal Ganglia Diseases

Organs/Tissues associated with anti-FOSB antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >265 publications with FOSB and Brain
 Blood Antibodies  >66 publications with FOSB and Blood
 Bone Antibodies  >31 publications with FOSB and Bone
 Muscle Antibodies  >30 publications with FOSB and Muscle
 Liver Antibodies  >17 publications with FOSB and Liver
 Heart Antibodies  >15 publications with FOSB and Heart
 Lung Antibodies  >13 publications with FOSB and Lung
 Eye Antibodies  >11 publications with FOSB and Eye
 Embryonic Tissue Antibodies  >9 publications with FOSB and Embryonic Tissue
 Intestine Antibodies  >8 publications with FOSB and Intestine
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