Mouse Anti-TFAP4 Monoclonal Antibody – Cat# MBS600334

Transcription Factor Ap-4 (TFAP4) Antibody – Mouse Monoclonal

Name: TFAP4 Antibody; Monoclonal; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS600334
Price: 850 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS600334

Transcription factor AP4 is a member of the basic-helix-loop-helix (bHLH) transcription factors, which bind to the E-box sequence in the promoters of their target genes. AP-4 has been shown to act both as a repressor and an activator for different target… More details

$850 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Transcription Factor AP-4 (TFAP4), Monoclonal Antibody

Full Product Name

Transcription Factor AP-4 (TFAP4, Activating Enhancer Binding Protein 4)

Product Gene Name

anti-TFAP4 antibody

Product Synonym Names

Anti -Transcription Factor AP-4 (TFAP4, Activating Enhancer Binding Protein 4)

Clonality

Monoclonal

Isotype

IgG1

Clone Number

8C336

Host

Mouse

Form/Format

Supplied as a sterile-filtered liquid in PBS, pH 7.4, 1% BSA, 0.05% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein G affinity chromatography.

Specificity

Recognizes human Transcription Factor AP-4.

Preparation and Storage

May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

38,726 Da

Chromosome Location

Chromosome: 16; NC_000016.9 (4307187..4323001, complement). Location: 16p13

OMIM

600743

3D Structure

ModBase 3D Structure for Q01664

Immunogen

Partial sequence of recombinant full-length protein to human Transcription Factor AP-4

Product Categories/Family for anti-TFAP4 antibody

Antibodies; Abs to Transcription Factors

Applications Tested/Suitable for anti-TFAP4 antibody

Western Blot (WB)

Application Notes for anti-TFAP4 antibody

Suitable for use in Western Blotting.
Dilution: Western Blotting: 1:1000-1:2000

Other Notes

Small volumes of anti-TFAP4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TFAP4 purchase

MBS600334 is an antibody targeting TFAP4. Also known as Transcription Factor AP-4 (TFAP4, Activating Enhancer Binding Protein 4). Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for TFAP4. It may not necessarily be applicable to this product.

NCBI GI #

4507447

NCBI GeneID

7023

NCBI Accession #

NP_003214.1

UniProt Primary Accession #

Q01664

UniProt Secondary Accession #

O60409

UniProt Related Accession #

Q01664; Q59GG3; Q6FHM5

GenBank Nucleotide #

NM_003223.2

NCBI Official Full Name

transcription factor AP-4

NCBI Official Synonym Full Names

transcription factor AP-4 (activating enhancer binding protein 4)

NCBI Official Symbol

TFAP4

NCBI Official Synonym Symbols

AP-4; bHLHc41

UniProt Protein Name

Transcription factor AP-4

UniProt Synonym Protein Names

Activating enhancer-binding protein 4; Class C basic helix-loop-helix protein 41

Protein Family

Transcription factor

UniProt Gene Name

TFAP4

UniProt Synonym Gene Names

BHLHC41

UniProt Entry Name

TFAP4_HUMAN

NCBI Protein Information

transcription factor AP-4; OTTHUMP00000159805; activating enhancer-binding protein 4; class C basic helix-loop-helix protein 41; transcription factor AP-4 (activating enhancer-binding protein 4)

NCBI Summary for TFAP4

Transcription factors of the basic helix-loop-helix-zipper (bHLH-ZIP) family contain a basic domain, which is used for DNA binding, and HLH and ZIP domains, which are used for oligomerization. Transcription factor AP4 activates both viral and cellular genes by binding to the symmetrical DNA sequence CAGCTG (Mermod et al., 1988 [PubMed 2833704]; Hu et al., 1990 [PubMed 2123466]).[supplied by OMIM]

UniProt Comments for TFAP4

AP-4: Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5'- CAGCTG-3'.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 16p13

Cellular Component: transcriptional repressor complex; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; protein homodimerization activity; DNA binding; protein heterodimerization activity; sequence-specific DNA binding; histone deacetylase binding; transcription coactivator activity

Biological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; negative regulation of cell proliferation; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; negative regulation of cyclin-dependent protein kinase activity; positive regulation of transcription from RNA polymerase II promoter; protein complex assembly; negative regulation of transcription, DNA-dependent; negative regulation of DNA binding

Research Articles on TFAP4

1. Activator protein-4 expression was associated with the expression of matrix metalloproteinase-9 and vascular endothelial growth factor in the advanced colorectal cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-TFAP4 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>3 publications with TFAP4 and Neoplasms
Ovarian Neoplasms Antibodies	>1 publications with TFAP4 and Ovarian Neoplasms
Cell Transformation, Neoplastic Antibodies	>1 publications with TFAP4 and Cell Transformation, Neoplastic
Breast Neoplasms Antibodies	>1 publications with TFAP4 and Breast Neoplasms
Neoplasms, Experimental Antibodies	>1 publications with TFAP4 and Neoplasms, Experimental
Genital Neoplasms, Female Antibodies	>1 publications with TFAP4 and Genital Neoplasms, Female