PKC Beta2 (PRKCB) Antibody – Rabbit Polyclonal

PKCB iso2: an AGC kinase of the PKC family. A classical PKC downstream of many mitogenic receptors. Activates the NF-kappaB signaling pathway in B cells after antigen-receptor signaling. Two splice-variant isoforms have been described.

Protein type: Protein kinase, Ser/Thr (non-receptor); Motility/polarity/chemotaxis; EC 2.7.11.13; Protein kinase, AGC; Kinase, protein; AGC group; PKC family; Alpha subfamily

Cellular Component: centrosome; membrane; brush border membrane; cytoplasm; plasma membrane; nucleus; cytosol

Molecular Function: protein kinase C activity; histone binding; zinc ion binding; metal ion binding; calcium channel regulator activity; nucleotide binding; protein kinase activity; transferase activity; protein serine/threonine kinase activity; protein binding; protein kinase C binding; androgen receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; transferase activity, transferring phosphorus-containing groups; kinase activity; chromatin binding; ATP binding

Biological Process: response to drug; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; B cell activation; immune system process; apoptosis; positive regulation of B cell receptor signaling pathway; negative regulation of insulin receptor signaling pathway; chromatin modification; regulation of dopamine secretion; protein amino acid phosphorylation; positive regulation of vascular endothelial growth factor receptor signaling pathway; activation of NF-kappaB transcription factor; regulation of transcription from RNA polymerase II promoter; cellular calcium ion homeostasis; positive regulation of angiogenesis; B cell receptor signaling pathway; regulation of transcription, DNA-dependent; calcium ion transport; regulation of growth; response to hypoxia; phosphorylation