A-Dystroglycan Antibody – Mouse Monoclonal

Dystroglycans are essential elements of the neuromuscularjunction (NMJ). The gene for dystroglycan is expressed as aprecursor protein that is post translationally cleaved into a156kD extracellular peripheral membrane protein called alphadystroglycan and a 43kD transmembrane protein, betadystroglycan. The latter protein contains a PPxY motif thatpromotes binding to WW domain containing proteins, such asutrophin and dystrophin. Phosphorylation at tyrosine 892within the PPxY motif may regulate c-Src interactions with betadystroglycan, as well as inhibit interactions with WW domainproteins. In skeletal muscle, beta dystroglycan is normallylocalized to the plasma membrane, however phosphorylationof Tyr892 leads to localization of beta dystroglycan toendosomal compartments along with c-Src. Thus,phosphorylation at Tyr892 may have important roles in alteringthe localization of beta dystroglycan during NMJ formation

Small volumes of anti-a-Dystroglycan antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS600655 is an antibody targeting a-Dystroglycan. Also known as a-Dystroglycan (Cranin). Reactive in Rabbit. Host: Mouse.