Mouse Anti-ALX1 Monoclonal Antibody – Cat# MBS601896

CART1 (ALX1) Antibody – Mouse Monoclonal

Name: ALX1 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS601896
Price: 850 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS601896

MBS601896 is an antibody targeting ALX1. Also known as CART1 (CART-1, Cartilage Homeoprotein 1, Cartilage Paired-class Homeoprotein 1, ALX Homeobox Protein 1, ALX1). Reactive in Human. Host: Mouse. More details

$850 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CART1 (ALX1), Monoclonal Antibody

Full Product Name

CART1 (CART-1, Cartilage Homeoprotein 1, Cartilage Paired-class Homeoprotein 1, ALX Homeobox Protein 1, ALX1)

Product Gene Name

anti-ALX1 antibody

Product Synonym Names

Anti -CART1 (CART-1, Cartilage Homeoprotein 1, Cartilage Paired-class Homeoprotein 1, ALX Homeobox Protein 1, ALX1)

Clonality

Monoclonal

Isotype

IgG1

Clone Number

8J101

Host

Mouse

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, 1% BSA and 0.05% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein G affinity chromatography.

Specificity

Recognizes human CART1.

Preparation and Storage

May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

36,961 Da

Chromosome Location

chromosome: 12; Location: 12q21.31

OMIM

601527

3D Structure

ModBase 3D Structure for Q15699

Immunogen

Partial sequence of recombinant full-length protein to human CART1

Product Categories/Family for anti-ALX1 antibody

Antibodies; Abs to Transcription Factors; Homeobox (HOX)

Applications Tested/Suitable for anti-ALX1 antibody

Western Blot (WB), Gel Shift Assay (GS/EMSA)

Application Notes for anti-ALX1 antibody

Suitable for use in Dot Blot and Western Blot.

Other Notes

Small volumes of anti-ALX1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ALX1. It may not necessarily be applicable to this product.

NCBI GI #

46946691

NCBI GeneID

8092

UniProt Primary Accession #

Q15699

UniProt Secondary Accession #

Q546C8; Q96FH4

UniProt Related Accession #

Q15699

NCBI Official Full Name

cartilage paired-class homeoprotein 1

NCBI Official Synonym Full Names

ALX homeobox 1

NCBI Official Symbol

ALX1

NCBI Official Synonym Symbols

FND3; CART1; ALX1

UniProt Protein Name

ALX homeobox protein 1

UniProt Synonym Protein Names

Cartilage homeoprotein 1

Protein Family

ALX homeobox protein

UniProt Gene Name

ALX1

UniProt Synonym Gene Names

CART1

UniProt Entry Name

ALX1_HUMAN

NCBI Protein Information

ALX homeobox protein 1; CART-1; cartilage paired-class homeoprotein 1

NCBI Summary for ALX1

The specific function of this gene has yet to be determined in humans; however, in rodents, it is necessary for survival of the forebrain mesenchyme and may also be involved in development of the cervix. Mutations in the mouse gene lead to neural tube defects such as acrania and meroanencephaly. [provided by RefSeq]

UniProt Comments for ALX1

Cart1: Transcriptional activator that acts at a palindromic recognition sequence to enhance the activity of the SV40 and TK promoters. Functions as a repressor with the prolactin promoter in vivo. May play a role in chondrocyte differentiation and may also influence cervix development. Defects in ALX1 are the cause of frontonasal dysplasia type 3 (FND3). The term frontonasal dysplasia describes an array of abnormalities affecting the eyes, forehead and nose and linked to midfacial dysraphia. The clinical picture is highly variable. Major findings include true ocular hypertelorism; broadening of the nasal root; median facial cleft affecting the nose and/or upper lip and palate; unilateral or bilateral clefting of the alae nasi; lack of formation of the nasal tip; anterior cranium bifidum occultum; a V-shaped or widow's peak frontal hairline. Belongs to the paired homeobox family.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 12q21.31

Cellular Component: nucleoplasm; Golgi apparatus; transcription factor complex; nucleus

Molecular Function: protein binding; protein heterodimerization activity; transcription corepressor activity; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; multicellular organismal development; positive regulation of transcription, DNA-dependent; palate development; negative regulation of transcription from RNA polymerase II promoter; embryonic skeletal morphogenesis; anterior/posterior pattern formation; neural tube closure; positive regulation of transcription from RNA polymerase II promoter; brain development; mesenchymal cell development; cartilage condensation; embryonic limb morphogenesis

Disease: Frontonasal Dysplasia 3

Research Articles on ALX1

1. Disruption of CART1 (ALX1) causes extreme microphthalmia and severe facial clefting.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ALX1 antibody

Reference Product	PubMed Publications
ALX4 antibody	>2 publications with ALX1 and ALX4
EP300 antibody	>1 publications with ALX1 and EP300
CREBBP antibody	>1 publications with ALX1 and CREBBP

Diseases associated with anti-ALX1 antibody

Disease Name	Pubmed Publications
FRONTONASAL DYSPLASIA 3 Antibodies	>1 publications with ALX1 and FRONTONASAL DYSPLASIA 3
Craniofacial Abnormalities Antibodies	>1 publications with ALX1 and Craniofacial Abnormalities

Organs/Tissues associated with anti-ALX1 antibody

Organ/Tissue Name	Pubmed Publications
Embryonic Tissue Antibodies	>2 publications with ALX1 and Embryonic Tissue
Connective Tissue Antibodies	>1 publications with ALX1 and Connective Tissue
Brain Antibodies	>1 publications with ALX1 and Brain