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Hepatocyte Growth Factor Activator Inhibitor 1 (SPINT1) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS602273

Hepatocyte Growth Factor Activator Inhibitor 1 (HAI-1), also known as Serine Protease Inhibitor, Kunitz-Type I (SPINT1), is an inhibitor of HGF Activator, a protease that activates HGF in response to tissue damage. More details

$1290 / 0.5 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Hepatocyte Growth Factor Activator Inhibitor 1 (SPINT1), Monoclonal Antibody
Full Product Name
Hepatocyte Growth Factor Activator Inhibitor 1 (HAI-1, Serine Protease Inhibitor Kunitz-Type I, SPINT1)
Product Gene Name
Product Synonym Names
Anti -Hepatocyte Growth Factor Activator Inhibitor 1 (HAI-1, Serine Protease Inhibitor Kunitz-Type I, SPINT1)
Clonality
Monoclonal
Isotype
IgG1
Clone Number
7H50
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a lyophilized powder from a 0.2um filtered solution in PBS, 5% trehalose. Reconstitute with 1ml sterile, ddH2O or sterile 40-50% glycerol.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human HAI-1.
Preparation and Storage
Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
58,398 Da
Chromosome Location
Chromosome: 15; NC_000015.9 (41136246..41149853). Location: 15q15.1
OMIM
605123
3D Structure
ModBase 3D Structure for O43278
Immunogen
NS0-derived recombinant human HAI-1 ectodomain (aa37-449)
Applications Tested/Suitable for anti-SPINT1 antibody
ELISA (EL/EIA)
Application Notes for anti-SPINT1 antibody
Suitable for use in ELISA.
Dilution: ELISA: 2-8ug/ml

Other Notes

Small volumes of anti-SPINT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SPINT1 purchase

MBS602273 is an antibody targeting SPINT1. Also known as Hepatocyte Growth Factor Activator Inhibitor 1 (HAI-1, Serine Protease Inhibitor Kunitz-Type I, SPINT1). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for SPINT1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
hepatocyte growth factor activator inhibitor 1B
NCBI Official Synonym Full Names
serine peptidase inhibitor, Kunitz type 1
NCBI Official Symbol
SPINT1
NCBI Official Synonym Symbols
HAI; HAI1; MANSC2
UniProt Protein Name
Kunitz-type protease inhibitor 1
UniProt Synonym Protein Names
Hepatocyte growth factor activator inhibitor type 1
UniProt Gene Name
SPINT1
UniProt Synonym Gene Names
HAI1; HAI-1
UniProt Entry Name
SPIT1_HUMAN
NCBI Protein Information
kunitz-type protease inhibitor 1; HAI-1; serine protease inhibitor, Kunitz type 1; hepatocyte growth factor activator inhibitor type 1

NCBI Summary for SPINT1

The protein encoded by this gene is a member of the Kunitz family of serine protease inhibitors. The protein is a potent inhibitor specific for HGF activator and is thought to be involved in the regulation of the proteolytic activation of HGF in injured tissues. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq, Jul 2008]
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UniProt Comments for SPINT1

SPINT1: Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14). 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 15q15.1

Cellular Component: extracellular space; membrane; extracellular region

Molecular Function: serine-type endopeptidase inhibitor activity

Biological Process: extracellular matrix organization and biogenesis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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