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DMC1 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS603391

Rad51 and disrupted meiotic cDNA1 (Dmc1) are the two eukaryotic DNA recombinases that participate in homology search and strand exchange reactions during homologous recombination mediated DNA repair. More details

$955 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
DMC1, Monoclonal Antibody
Full Product Name
DMC1 (Disrupted Meiotic cDNA 1 Homolog, dJ199H16.1, DMC 1, DMC1H, HsLim15, Meiotic Recombination Protein DMC1/LIM15 Homolog)
Product Gene Name
Product Synonym Names
Anti -DMC1 (Disrupted Meiotic cDNA 1 Homolog, dJ199H16.1, DMC 1, DMC1H, HsLim15, Meiotic Recombination Protein DMC1/LIM15 Homolog)
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
8J1306
Host
Mouse
Species Reactivity
Bovine, Human, Mouse, Rat
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Mouse ascites
Specificity
Specific for DMC1 - does not crossreact with the related protein Rad51. Species Crossreactivity: Crossreacts with Human, Mouse, Rat and bovine. Not yet tested in other species.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
37,681 Da
Chromosome Location
Chromosome: 22; NC_000022.10 (38914954..38966189, complement). Location: 22q13.1
OMIM
602721
3D Structure
ModBase 3D Structure for Q14565
Immunogen
Recombinant fusion protein (Human).
Cellular Localization
Nuclear

Product Categories/Family for anti-DMC1 antibody

Applications Tested/Suitable for anti-DMC1 antibody
Western Blot (WB), Immunoprecipitation (IP), Immunofluorescence (IF)
Application Notes for anti-DMC1 antibody
Suitable for use in Immunofluorescence, Western Blot and Immunoprecipitation.

Other Notes

Small volumes of anti-DMC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DMC1 purchase

MBS603391 is an antibody targeting DMC1. Also known as DMC1 (Disrupted Meiotic cDNA 1 Homolog, dJ199H16.1, DMC 1, DMC1H, HsLim15, Meiotic Recombination Protein DMC1/LIM15 Homolog). Reactive in Bovine, Human, Mouse, Rat. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for DMC1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
DMC1
NCBI Official Synonym Full Names
DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)
NCBI Official Symbol
DMC1
NCBI Official Synonym Symbols
DMC1H; LIM15; HsLim15; MGC150472; MGC150473; dJ199H16.1
UniProt Protein Name
Meiotic recombination protein DMC1/LIM15 homolog
UniProt Gene Name
DMC1
UniProt Synonym Gene Names
DMC1H; LIM15
UniProt Entry Name
DMC1_HUMAN
NCBI Protein Information
meiotic recombination protein DMC1/LIM15 homolog; DMC1 homologue; OTTHUMP00000199098; OTTHUMP00000199222; disrupted meiotic cDNA1, yeast, homolog of

NCBI Summary for DMC1

The protein encoded by this gene is essential for meiotic homologous recombination. Genetic recombination in meiosis plays an important role in generating diversity of genetic information. The product of this gene is structurally and evolutionary related to the products of the yeast RAD51 and E. coli RecA genes. Alternative splice variants of this gene have been described but their full-length nature has not been determined. [provided by RefSeq]
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UniProt Comments for DMC1

DMC1: May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks. Belongs to the RecA family. DMC1 subfamily.

Protein type: DNA repair, damage; Cell cycle regulation; Cell development/differentiation

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: chromosome, telomeric region; condensed nuclear chromosome; chromosome; nucleus

Molecular Function: DNA-dependent ATPase activity; protein binding; DNA binding; ATP binding

Biological Process: meiosis; male meiosis I; ovarian follicle development; meiotic recombination; synapsis; female gamete generation; spermatogenesis; oocyte maturation; spermatid development
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DMC1 antibody

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