AP1G1 Antibody – Mouse Monoclonal

Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

AP1G1: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Belongs to the adaptor complexes large subunit family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 16q23

Cellular Component: Golgi apparatus; cytoplasmic vesicle membrane; clathrin adaptor complex; clathrin-coated vesicle; intracellular membrane-bound organelle; lysosomal membrane; clathrin coated vesicle membrane; AP-type membrane coat adaptor complex; cytosol; Golgi membrane; recycling endosome; membrane; perinuclear region of cytoplasm; cytoplasm; trans-Golgi network membrane

Molecular Function: protein binding; kinesin binding; transporter activity; GTP-dependent protein binding; Rab GTPase binding; protein transporter activity

Biological Process: intracellular protein transport; positive regulation of natural killer cell degranulation; viral reproduction; melanosome organization and biogenesis; antigen processing and presentation of exogenous peptide antigen via MHC class II; post-Golgi vesicle-mediated transport; positive regulation of natural killer cell mediated cytotoxicity; regulation of defense response to virus by virus