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ADAM 33 (ADAM33) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS606659

ADAM33 is a widely expressed member of the ADAM family of transmembrane proteins. It contains a metalloprotease-like domain, disintegrin cell adhesion domain, and cysteine rich domain. ADAM33 is involved in the maintenance of airway function, and ADAM33… More details

$1000 / 0.1 mg +1 FREE 8GB USB
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Testing Data View PDF
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Product Overview

Online Datasheet in PDF
Product Name
ADAM 33 (ADAM33), Monoclonal Antibody
Full Product Name
ADAM 33 (A Disintegrin and Metalloprotease 33, A Disintegrin and Metalloproteinase Domain 33, HGNC:15478, DJ964F7.1, DKFZp434K0521, FLJ35308, FLJ36751, MGC71889, Disintegrin and Reprolysin Metalloproteinase Family Protein, Metalloprotease Disintegrin)
Product Gene Name
anti-ADAM33 antibody
Product Synonym Names
Anti -ADAM 33 (A Disintegrin and Metalloprotease 33, A Disintegrin and Metalloproteinase Domain 33, HGNC:15478, DJ964F7.1, DKFZp434K0521, FLJ35308, FLJ36751, MGC71889, Disintegrin and Reprolysin Metalloproteinase Family Protein, Metalloprotease Disintegrin)
Clonality
Monoclonal
Isotype
IgG1
Clone Number
9H38
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a lyophilized powder in 0.2um sterile-filtered solution, PBS, 5% trehalose. Reconstitute with 40-50% glycerol, PBS.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human ADAM33.
Preparation and Storage
Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
87,668 Da
Chromosome Location
chromosome: 20; Location: 20p13
3D Structure
ModBase 3D Structure for A2A2L3
Immunogen
CHO-derived, recombinant human ADAM33 aa30-501; #Q9BZ11.

Product Categories/Family for anti-ADAM33 antibody

Antibodies; Abs to Matrix Metalloproteinases
Applications Tested/Suitable for anti-ADAM33 antibody
ELISA (EL/EIA), Immunoprecipitation (IP), Flow Cytometry (FC/FACS)
Application Notes for anti-ADAM33 antibody
Suitable for use in Flow Cytometry, ELISA, and Immunoprecipitation.
Dilution: Flow Cytometry: 25ug/ml
ELISA: 0.5-1.0ug/mL
Immunoprecipitation: 25ug/mL

Testing Data of anti-ADAM33 antibody

A549 cells were stained with MBS606659, filled histogram) or isotype control, open histogram) followed by PE-conjugated anti-mouse antibody.
Mouse Anti-ADAM33 Monoclonal Antibody – Cat# MBS606659

Other Notes

Small volumes of anti-ADAM33 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ADAM33 purchase

MBS606659 is an antibody targeting ADAM33. Also known as ADAM 33 (A Disintegrin and Metalloprotease 33, A Disintegrin and Metalloproteinase Domain 33, HGNC:15478, DJ964F7.1, DKFZp434K0521, FLJ35308, FLJ36751, MGC71889, Disintegrin and Reprolysin Metalloproteinase Family Protein, Metalloprotease Disintegrin). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for ADAM33. It may not necessarily be applicable to this product.

NCBI GI #
123233702
NCBI GeneID
80332
UniProt Primary Accession #
A2A2L3
UniProt Related Accession #
Q08AM2; Q08AM3; Q6P5U4; Q7Z7E0; Q7Z7E1; Q7Z7E2; Q7Z7E3; Q7Z7E5; Q8N6B9; Q8N8Z9
NCBI Official Full Name
ADAM metallopeptidase domain 33
NCBI Official Synonym Full Names
ADAM metallopeptidase domain 33
NCBI Official Symbol
ADAM33
NCBI Official Synonym Symbols
FLJ35308; FLJ36751; MGC71889; C20orf153; DJ964F7.1; MGC149823; DKFZp434K0521; ADAM33
UniProt Protein Name
ADAM metallopeptidase domain 33
Protein Family
Disintegrin and metalloproteinase domain-containing protein
UniProt Gene Name
ADAM33
UniProt Entry Name
A2A2L3_HUMAN
NCBI Protein Information
disintegrin and metalloproteinase domain-containing protein 33; ADAM 33; a disintegrin and metalloprotease 33; a disintegrin and metalloproteinase domain 33; disintegrin and reprolysin metalloproteinase family protein

NCBI Summary for ADAM33

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This protein is a type I transmembrane protein implicated in asthma and bronchial hyperresponsiveness. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq]
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UniProt Comments for ADAM33

Sequence similarities: Contains 1 disintegrin domain. RuleBase RU004074 SAAS SAAS001762Contains 1 peptidase M12B domain. RuleBase RU004141 SAAS SAAS001762

Research Articles on ADAM33

1. The polymorphism of T(1) locus allele in ADAM33 gene is associated with the susceptibility to asthma in South China Han population.
2. Our findings suggest a relevant role of ADAM33 in thepathogenesis of asthma in this population in Cartagena, Colombia.
3. preliminary results suggest an association between ADAM33 polymorphisms and COPD in a Chinese Han population
4. identification of ADAM33 as a psoriasis susceptibility gene identified by positional cloning in an outbred population should provide insights into the pathogenesis and natural history of this common disease
5. These results support the note that Th2 cytokines can up-regulate the expression of ADAM33 mRNA and ADAM33 may play an important role in the development of airway remodeling in allergen-induced chronic airway inflammation.
6. Adam33/Adam33 shows 2 significant increments in expression during lung morphogenesis, suggesting important developmental regulation.
7. The SNPs (V4 G/C, T2 A/G, T1 G/A, and Q - 1A/G) of the ADAM33 gene may be the causal variants in allergic rhinitis and asthma
8. Smoke exposure interacts with ADAM33 polymorphisms in the development of lung function and hyperresponsiveness.
9. First epidemiological study on the relationship between polymorphisms in the ADAM33 gene and the risk of atopic dermatitis. The rs2853209 SNP in the ADAM33 gene was significantly associated with the risk of AD in Japanese children.
10. Adam33 polymorphisms are associated with chronic obstructive pulmonary disease and lung function in long-term tobacco smokers.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-ADAM33 antibody

 Disease Name  Pubmed Publications
 Chronic Disease Antibodies  >25 publications with ADAM33 and Chronic Disease
 Bronchial Hyperreactivity Antibodies  >20 publications with ADAM33 and Bronchial Hyperreactivity
 Hyperplasia Antibodies  >3 publications with ADAM33 and Hyperplasia
 Diabetes Mellitus Antibodies  >2 publications with ADAM33 and Diabetes Mellitus
 Pregnancy Complications Antibodies  >2 publications with ADAM33 and Pregnancy Complications
 ASTHMA, NASAL POLYPS, AND ASPIRIN INTOLERANCE Antibodies  >1 publications with ADAM33 and ASTHMA, NASAL POLYPS, AND ASPIRIN INTOLERANCE
 Myocardial Ischemia Antibodies  >1 publications with ADAM33 and Myocardial Ischemia
 Heart Diseases Antibodies  >1 publications with ADAM33 and Heart Diseases
 Cardiovascular Diseases Antibodies  >1 publications with ADAM33 and Cardiovascular Diseases
 Colorectal Neoplasms Antibodies  >1 publications with ADAM33 and Colorectal Neoplasms

Organs/Tissues associated with anti-ADAM33 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >52 publications with ADAM33 and Lung
 Muscle Antibodies  >24 publications with ADAM33 and Muscle
 Vascular Antibodies  >7 publications with ADAM33 and Vascular
 Embryonic Tissue Antibodies  >6 publications with ADAM33 and Embryonic Tissue
 Skin Antibodies  >6 publications with ADAM33 and Skin
 Brain Antibodies  >4 publications with ADAM33 and Brain
 Testis Antibodies  >2 publications with ADAM33 and Testis
 Stomach Antibodies  >1 publications with ADAM33 and Stomach
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