Rabbit Anti-ACSS2 Monoclonal Antibody – Cat# MBS606941

Western blot analysis of extracts from various cell types using MBS606941.

Acetyl-Coenzyme A Synthetase, Cytoplasmic (ACSS2) Antibody – Rabbit Monoclonal

Name: ACSS2 Antibody; Monoclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS606941
Price: 565 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS606941

Cytoplasmic acetyl-CoA synthetase (AceCS1) catalyzes the conversion of acetate and CoA to acetyl-CoA (1, 2). Acetyl-CoA synthesized by AceCS1 is used for fatty acid and lipid biosynthesis (1, 2). Studies suggest that this enzyme is regulated by sterol… More details

$565 / 0.02 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Acetyl-Coenzyme A Synthetase, Cytoplasmic (ACSS2), Monoclonal Antibody

Full Product Name

Acetyl-Coenzyme A Synthetase, Cytoplasmic (Acetyl-CoA Synthetase, AceCS1, AceCS, ACS, ACSA, Acyl-CoA Synthetase Short-chain Family Member 2, ACAS2, ACSS2, Acetate-CoA Ligase, Acyl-activating Enzyme, dJ1161H23.1, DKFZp762G026)

Product Gene Name

anti-ACSS2 antibody

Product Synonym Names

Anti -Acetyl-Coenzyme A Synthetase, Cytoplasmic (Acetyl-CoA Synthetase, AceCS1, AceCS, ACS, ACSA, Acyl-CoA Synthetase Short-chain Family Member 2, ACAS2, ACSS2, Acetate-CoA Ligase, Acyl-activating Enzyme, dJ1161H23.1, DKFZp762G026)

Clonality

Monoclonal

Isotype

IgG

Clone Number

10g125

Host

Rabbit

Species Reactivity

Human, Monkey, Mouse, Rat

Form/Format

Supplied as a liquid in 10mM sodium HEPES pH 7.5, 150mM NaCl, 0.1mg/ml BSA, < 0.02% sodium azide, 50% glycerol.

Purity/Purification

Supernatant
Supernatant

Specificity

Recognizes endogenous levels of human total cytoplasmic acetyl-CoA synthetase (AceCS1). Species crossreactivity: Mouse, rat and monkey.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

78,580 Da

Chromosome Location

Chromosome: 20; NC_000020.10 (33462766..33515769). Location: 20q11.22

OMIM

605832

3D Structure

ModBase 3D Structure for Q9NR19

Immunogen

Synthetic peptide corresponding to the sequence of human cytoplasmic acetyl-CoA synthetase (AceCS1).

Product Categories/Family for anti-ACSS2 antibody

Antibodies; Abs to Enzymes; Synthetase

Applications Tested/Suitable for anti-ACSS2 antibody

Western Blot (WB), Immunoprecipitation (IP)

Application Notes for anti-ACSS2 antibody

Suitable for use in Western Blot and Immunoprecipitation.
Dilution: Western Blot: 1:10-1:50
Immunoprecipitation: 1:50

Other Notes

Small volumes of anti-ACSS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ACSS2 purchase

MBS606941 is an antibody targeting ACSS2. Also known as Acetyl-Coenzyme A Synthetase, Cytoplasmic (Acetyl-CoA Synthetase, AceCS1, AceCS, ACS, ACSA, Acyl-CoA Synthetase Short-chain Family Member 2, ACAS2, ACSS2, Acetate-CoA Ligase, Acyl-activating Enzyme, dJ1161H23.1, DKFZp762G026). Reactive in Human, Monkey, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ACSS2. It may not necessarily be applicable to this product.

NCBI GI #

8923896

NCBI GeneID

55902

NCBI Accession #

NP_061147.1

UniProt Primary Accession #

Q9NR19

UniProt Secondary Accession #

Q5QPH2; Q96EL0; Q9NQP7; Q9UJ15

UniProt Related Accession #

Q5QPH3; Q68CU9; Q6DKJ3; Q8N238; Q96FY7; Q9H9U4; Q9NR19

GenBank Nucleotide #

NM_018677.3

NCBI Official Full Name

acetyl-coenzyme A synthetase, cytoplasmic isoform 1

NCBI Official Synonym Full Names

acyl-CoA synthetase short-chain family member 2

NCBI Official Symbol

ACSS2

NCBI Official Synonym Symbols

ACS; ACSA; ACAS2; ACECS; dJ1161H23.1; DKFZp762G026

UniProt Protein Name

Acetyl-coenzyme A synthetase, cytoplasmic

UniProt Synonym Protein Names

Acetate--CoA ligase; Acetyl-CoA synthetase; ACS; AceCS; Acyl-CoA synthetase short-chain family member 2; Acyl-activating enzyme

Protein Family

Acetyl-coenzyme A synthetase

UniProt Gene Name

ACSS2

UniProt Synonym Gene Names

ACAS2

UniProt Entry Name

ACSA_HUMAN

NCBI Protein Information

acetyl-coenzyme A synthetase, cytoplasmic; OTTHUMP00000030713; OTTHUMP00000030717; acetate thiokinase; acetate-CoA ligase; acyl-activating enzyme; cytoplasmic acetyl-coenzyme A synthetase; acetyl-Coenzyme A synthetase 2 (ADP forming)

NCBI Summary for ACSS2

This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq]

UniProt Comments for ACSS2

ACSS2: Activates acetate so that it can be used for lipid synthesis or for energy generation. Monomer. Belongs to the ATP-dependent AMP-binding enzyme family.

Protein type: Carbohydrate Metabolism - pyruvate; Ligase; Carbohydrate Metabolism - propanoate; EC 6.2.1.1; Carbohydrate Metabolism - glycolysis and gluconeogenesis

Chromosomal Location of Human Ortholog: 20q11.22

Cellular Component: nucleoplasm; intracellular membrane-bound organelle; cytoplasm; cytosol

Molecular Function: acetate-CoA ligase activity; ATP binding; AMP binding

Biological Process: acetyl-CoA biosynthetic process from acetate; xenobiotic metabolic process; lipid biosynthetic process; ethanol oxidation; propionate biosynthetic process; acetate biosynthetic process

Research Articles on ACSS2

1. Ritonavir (at 100 mg once daily and 100 mg twice daily significantly down-regulated acyl-CoA synthetase short-chain family member 2 in 20 healthy individuals.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ACSS2 antibody

Products by Pathway	Pathway Diagram
Biological Oxidations Pathway antibodies	Biological Oxidations Pathway Diagram
Ethanol Oxidation Pathway antibodies	Ethanol Oxidation Pathway Diagram
Fatty Acid Beta Oxidation Pathway antibodies	Fatty Acid Beta Oxidation Pathway Diagram
Fatty Acid Biosynthesis Pathway antibodies	Fatty Acid Biosynthesis Pathway Diagram
Glycolysis / Gluconeogenesis Pathway antibodies	Glycolysis / Gluconeogenesis Pathway Diagram
Glycolysis / Gluconeogenesis Pathway antibodies	Glycolysis / Gluconeogenesis Pathway Diagram
Metabolic Pathways antibodies	Metabolic Pathways Diagram
Phase 1 - Functionalization Of Compounds Pathway antibodies	Phase 1 - Functionalization Of Compounds Pathway Diagram
Propanoate Metabolism Pathway antibodies	Propanoate Metabolism Pathway Diagram
Propanoate Metabolism Pathway antibodies	Propanoate Metabolism Pathway Diagram

Diseases associated with anti-ACSS2 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>3 publications with ACSS2 and Neoplasms
Obesity Antibodies	>2 publications with ACSS2 and Obesity
Carcinoma Antibodies	>1 publications with ACSS2 and Carcinoma
Hyperglycemia Antibodies	>1 publications with ACSS2 and Hyperglycemia
Weight Gain Antibodies	>1 publications with ACSS2 and Weight Gain
Inflammation Antibodies	>1 publications with ACSS2 and Inflammation
Insulin Resistance Antibodies	>1 publications with ACSS2 and Insulin Resistance
Carcinoma, Hepatocellular Antibodies	>1 publications with ACSS2 and Carcinoma, Hepatocellular
Liver Neoplasms Antibodies	>1 publications with ACSS2 and Liver Neoplasms
Liver Diseases Antibodies	>1 publications with ACSS2 and Liver Diseases

Organs/Tissues associated with anti-ACSS2 antibody

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>3 publications with ACSS2 and Liver
Blood Antibodies	>3 publications with ACSS2 and Blood
Connective Tissue Antibodies	>1 publications with ACSS2 and Connective Tissue
Mammary Gland Antibodies	>1 publications with ACSS2 and Mammary Gland
Heart Antibodies	>1 publications with ACSS2 and Heart