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KCNQ4 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS607391

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that… More details

$815 / 0.1 mg +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
KCNQ4, Monoclonal Antibody
Full Product Name
KCNQ4 (KCNQ 4, DFNA2, KQT-like 4, Kv7.4, Potassium Channel KQT-like 4, Potassium Channel Subunit alpha KvLQT4, Potassium Voltage Gated Channel KQT-like Protein 4, Potassium Voltage Gated Channel KQT-like Subfamily Member 4, Potassium Voltage Gated Channel
Product Gene Name
anti-Kcnq4 antibody
Product Synonym Names
Anti -KCNQ4 (KCNQ 4, DFNA2, KQT-like 4, Kv7.4, Potassium Channel KQT-like 4, Potassium Channel Subunit alpha KvLQT4, Potassium Voltage Gated Channel KQT-like Protein 4, Potassium Voltage Gated Channel KQT-like Subfamily Member 4, Potassium Voltage Gated Channel
Clonality
Monoclonal
Isotype
IgG1
Clone Number
10F743
Host
Mouse
Species Reactivity
Human, Mouse, Rat
Form/Format
Supplied as a liquid in PBS, pH7.4, 0.09% sodium azide, 50% glycerol.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human KCNQ4. Species Crossreactivity: rat.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
18,845 Da
Chromosome Location
Chromosome: 5; NC_005104.2 (141289211..141339803, complement). Location: 5q36
3D Structure
ModBase 3D Structure for Q9JK96
Immunogen
Fusion protein amino acid 2-77 of human KCNQ4 (Kv7.4, KvLQT4, accession number P56696).

Product Categories/Family for anti-Kcnq4 antibody

Antibodies; Abs to Ion Channel
Applications Tested/Suitable for anti-Kcnq4 antibody
Western Blot (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC)
Application Notes for anti-Kcnq4 antibody
Suitable for use in Western Blot, Immunoprecipitation and Immunocytochemistry.
Dilution: Western Blot: 1-10ug/ml
Immunocytochemistry: 0.1-1ug/m

Other Notes

Small volumes of anti-Kcnq4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Kcnq4 purchase

MBS607391 is an antibody targeting Kcnq4. Also known as KCNQ4 (KCNQ 4, DFNA2, KQT-like 4, Kv7.4, Potassium Channel KQT-like 4, Potassium Channel Subunit alpha KvLQT4, Potassium Voltage Gated Channel KQT-like Protein 4, Potassium Voltage Gated Channel KQT-like Subfamily Member 4, Potassium Voltage Gated Channel. Reactive in Human, Mouse, Rat. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for Kcnq4. It may not necessarily be applicable to this product.

NCBI GI #
7671228
NCBI GeneID
298496
UniProt Primary Accession #
Q9JK96
UniProt Related Accession #
Q9JK96
NCBI Official Full Name
KCNQ4
NCBI Official Synonym Full Names
potassium voltage-gated channel, KQT-like subfamily, member 4
NCBI Official Symbol
Kcnq4
NCBI Official Synonym Symbols
Kcnq4
UniProt Protein Name
Potassium voltage-gated channel subfamily KQT member 4
UniProt Synonym Protein Names
KQT-like 4; Potassium channel subunit alpha KvLQT4; Voltage-gated potassium channel subunit Kv7.4
Protein Family
Potassium voltage-gated channel subfamily
UniProt Gene Name
Kcnq4
UniProt Entry Name
KCNQ4_RAT
NCBI Protein Information
potassium voltage-gated channel subfamily KQT member 4; KQT-like 4; potassium channel subunit alpha KvLQT4; voltage-gated potassium channel subunit Kv7.4; potassium voltage-gated channel, subfamily Q, member 4

NCBI Summary for Kcnq4

mutations in the human gene causes autosomal dominant, non-syndromic, progressive hearing loss [RGD]

UniProt Comments for Kcnq4

KCNQ4: Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinnic receptors. Defects in KCNQ4 are the cause of deafness autosomal dominant type 2A (DFNA2A). DFNA2A is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.4/KCNQ4 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: voltage-gated potassium channel complex; neuron projection; cytoplasm; plasma membrane; basal plasma membrane

Molecular Function: voltage-gated potassium channel activity; potassium channel activity

Biological Process: inner ear morphogenesis; sensory perception of sound; negative regulation of synaptic transmission, dopaminergic; potassium ion transport
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Research Articles on Kcnq4

1. KCNQ4 potassium channel contributes to the regulation of myogenic control of cerebral artery diameter.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Kcnq4 antibody

 Products by Pathway  Pathway Diagram
 Cholinergic Synapse Pathway antibodies  Cholinergic Synapse Pathway Diagram

Organs/Tissues associated with anti-Kcnq4 antibody

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >1 publications with Kcnq4 and Eye
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