Dopamine Receptor, D3 Antibody – Mouse Monoclonal

The 5 major receptors for the monoamine neurotransmitter dopamine are usually classified into two subfamilies based on biochemical, pharmacological and physiological properties. D1 subfamily receptors include the D1 and D5 (D1b) receptors. D2 subfamily receptors include the D2, D3, and D4 receptors. Each of these receptors exhibit the general structural characteristics of G-protein coupled receptors with seven transmembrane domains, an extracellular N-terminal domain, three extracellular loops, and four cytoplasmic loops, the last of which is formed by membrane insertion of a palmitoylated residue located in the intracellular C-terminal domain. The third intracellular loop is thought to be important for interaction with G-proteins. D1 subfamily receptors are characterized by short third intracellular loops and long C-terminal domains and generally stimulate adenylate cyclase production. D2 subfamily receptors have long third intracellular loops and short C-terminal domains and in general, appear to inhibit adenylate cyclase production. The D2 and D3 receptors vary in certain tissues and species as a result of alternative splicing.

Small volumes of anti-Dopamine Receptor, D3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS609203 is an antibody targeting Dopamine Receptor, D3. Reactive in Human, Monkey, Rat. Host: Mouse.