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BAFF Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS539429

MBS539429 is an active protein targeting BAFF. Also known as BAFF Receptor protein. Host: Human. Purified recombinant Human BAFF Receptor protein More details

$685 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
BAFF, Active Protein
Full Product Name
BAFF Receptor protein
Product Gene Name
BAFF active protein
Product Synonym Names
BAFFR protein; TNFRSF13C protein
Sequence
Region of BAFF Receptor protein correspond ing to amino acids MRRGPRSLRG RDAPAPTPCV PAECFDLLVR HCVACGLLRT PRPKPAGASS PAPRTALQPQ ESVGAGAGEA ALPLPG.
Host
Human
Form/Format
Supplied as a lyophilized powder.
Purity/Purification
> 95% pure
Concentration
50ug, lyophilized (lot specific)
Preparation and Storage
Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Molecular Weight
7.7 kDa
3D Structure
ModBase 3D Structure for Q5H8V1
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Protein Type
Recombinant
Bioactivity
Determined by its ability to bl degree Ck BAFF induced mouse splen degree Cyte survival. The expected ED50 for this effect is 2.0-4.0 ug/ml in the presence of 1.0ug/ml of human soluble BAFF.
Endotoxin Levels
Endotoxin level is less than 0.1 ng per ug (1 EU/ug)
Expression System
E Coli

Product Categories/Family for BAFF active protein

Cytokines & Growth Factors
Applications Tested/Suitable for BAFF active protein
User optimized

Other Notes

Small volumes of BAFF active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for BAFF. It may not necessarily be applicable to this product.

NCBI GI #
15208475
NCBI GeneID
115650
NCBI Accession #
AAK91826.1
UniProt Primary Accession #
Q5H8V1
UniProt Related Accession #
Q96RJ3
NCBI Official Full Name
BAFF receptor
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 13C
NCBI Official Symbol
TNFRSF13C
NCBI Official Synonym Symbols
BAFFR; CD268; CVID4; BAFF-R; BROMIX; prolixin
UniProt Protein Name
BAFF receptor
UniProt Synonym Protein Names
BAFF receptor
Protein Family
Tumor necrosis factor receptor superfamily
UniProt Gene Name
TNFRSF13C
UniProt Entry Name
Q5H8V1_HUMAN
NCBI Protein Information
tumor necrosis factor receptor superfamily member 13C

NCBI Summary for BAFF

B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. [provided by RefSeq, Jul 2008]
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UniProt Comments for BAFF

BAFF-R: B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response. Defects in TNFRSF13C are the cause of immunodeficiency common variable type 4 (CVID4); also called antibody deficiency due to BAFFR defect. CVID4 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell surface; Receptor, misc.; Membrane protein, integral; Cell cycle regulation

Chromosomal Location of Human Ortholog: 22q13.1-q13.31

Cellular Component: integral to membrane; external side of plasma membrane

Biological Process: B cell costimulation; B cell homeostasis; T cell costimulation; positive regulation of germinal center formation; positive regulation of B cell proliferation; positive regulation of T cell proliferation; positive regulation of interferon-gamma biosynthetic process

Disease: Immunodeficiency, Common Variable, 2; Immunodeficiency, Common Variable, 4
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Research Articles on BAFF

1. In view of the restricted expression of the BAFF-R on normal cells and the multiple anti-pre-B ALL activities stimulated by this antibody, a further examination of its use for treatment of pre-B ALL is warranted.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with BAFF active protein

 Reference Product  PubMed Publications
 TNFSF13B active protein  >123 publications with BAFF and TNFSF13B
 TNFRSF17 active protein  >59 publications with BAFF and TNFRSF17
 TNFRSF13B active protein  >57 publications with BAFF and TNFRSF13B
 BCR active protein  >23 publications with BAFF and BCR
 TRAF3 active protein  >8 publications with BAFF and TRAF3
 TRAF2 active protein  >4 publications with BAFF and TRAF2
 BTK active protein  >3 publications with BAFF and BTK
 REL active protein  >3 publications with BAFF and REL
 RELA active protein  >2 publications with BAFF and RELA

Pathways associated with BAFF active protein

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 NF-kappa B Signaling Pathway antibodies  NF-kappa B Signaling Pathway Diagram
 Primary Immunodeficiency Pathway antibodies  Primary Immunodeficiency Pathway Diagram
 Primary Immunodeficiency Pathway antibodies  Primary Immunodeficiency Pathway Diagram

Diseases associated with BAFF active protein

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >142 publications with BAFF and Necrosis
 Immune System Diseases Antibodies  >105 publications with BAFF and Immune System Diseases
 Inflammation Antibodies  >23 publications with BAFF and Inflammation
 Common Variable Immunodeficiency Antibodies  >12 publications with BAFF and Common Variable Immunodeficiency
 Kidney Diseases Antibodies  >8 publications with BAFF and Kidney Diseases
 Hyperplasia Antibodies  >6 publications with BAFF and Hyperplasia
 Demyelinating Diseases Antibodies  >4 publications with BAFF and Demyelinating Diseases
 Atherosclerosis Antibodies  >4 publications with BAFF and Atherosclerosis
 Skin Diseases Antibodies  >4 publications with BAFF and Skin Diseases
 Hypertrophy Antibodies  >4 publications with BAFF and Hypertrophy

Organs/Tissues associated with BAFF active protein

 Organ/Tissue Name  Pubmed Publications
 Lymph Node Antibodies  >14 publications with BAFF and Lymph Node
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