Goat Anti-LILRB5 Polyclonal Antibody – Cat# MBS610400

LILRB5 Antibody – Goat Polyclonal

Name: LILRB5 Antibody; Polyclonal; Goat; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS610400
Price: 1120 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS610400

Human LIR-8 (also known as CD85c and LILRB5) is a 587 amino acid transmembrane protein of the family of Leukocyte Immunoglobin-like Receptors. LIR-8 has a long N-terminus extracellular domain with four C2-type lg-like domains, and a short cytoplasmic tail… More details

$1120 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

LIR-8 (LILRB5), Polyclonal Antibody

Full Product Name

LIR-8 (Leukocyte Immunoglobulin-like Receptor 8, CD85c)

Product Gene Name

anti-LILRB5 antibody

Product Synonym Names

Anti -LIR-8 (Leukocyte Immunoglobulin-like Receptor 8, CD85c)

Clonality

Polyclonal

Isotype

IgG

Host

Goat

Species Reactivity

Human

Form/Format

Supplied as a lyophilized powder from PBS, pH7.4 5% trehalose. Reconsitute with 500ul sterile PBS.

Purity/Purification

Affinity Purified
Purified by immunoaffinity chromatography

Concentration

~0.2mg/ml (after reconstitution) (lot specific)

Specificity

Recognizes human LIR-8, Shows <20% crossreactivity with rhLIR-4. ~10% with rhILT5, rhLIR-5, rhLIR-6, and rhLILRA5 amd <5% with rhILT2, rhILT4, and rhLIR-7.

Preparation and Storage

Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile PBS with 40-50% glycerol and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

64,126 Da

Chromosome Location

Chromosome: 19; NC_000019.9 (54754270..54761167, complement). Location: 19q13.4

OMIM

604814

3D Structure

ModBase 3D Structure for O75023

Immunogen

NS0-derived rhLIR-8 (aa18-456) isoform

Immunogen Information

Recombinant protein corresponding to aa 18-456 from human LIR-8, expressed in NS0 cells (O75023)

Product Categories/Family for anti-LILRB5 antibody

Antibodies; Abs to Receptors

Applications Tested/Suitable for anti-LILRB5 antibody

ELISA (EL/EIA), Western Blot (WB), Flow Cytometry (FC/FACS)

Application Notes for anti-LILRB5 antibody

Western Blot: 0.1ug/ml
Flow Cytometry: 2.5ug/10e5 cells. Validated using human peripheral blood monocytes and granulocutes.
Optimal dilutions to be determined by the researcher.

Other Notes

Small volumes of anti-LILRB5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LILRB5 purchase

MBS610400 is an antibody targeting LILRB5. Also known as LIR-8 (Leukocyte Immunoglobulin-like Receptor 8, CD85c). Reactive in Human. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for LILRB5. It may not necessarily be applicable to this product.

NCBI GI #

125987593

NCBI GeneID

10990

NCBI Accession #

NP_001074912.1

UniProt Primary Accession #

O75023

UniProt Secondary Accession #

Q8N760

UniProt Related Accession #

O75023

GenBank Nucleotide #

NM_001081443.1

NCBI Official Full Name

leukocyte immunoglobulin-like receptor subfamily B member 5 isoform 3

NCBI Official Synonym Full Names

leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5

NCBI Official Symbol

LILRB5

NCBI Official Synonym Symbols

LIR8; CD85C; LIR-8

UniProt Protein Name

Leukocyte immunoglobulin-like receptor subfamily B member 5

UniProt Synonym Protein Names

CD85 antigen-like family member C; Leukocyte immunoglobulin-like receptor 8

Protein Family

Leukocyte immunoglobulin-like receptor subfamily

UniProt Gene Name

LILRB5

UniProt Synonym Gene Names

LIR8; LIR-8

UniProt Entry Name

LIRB5_HUMAN

NCBI Protein Information

leukocyte immunoglobulin-like receptor subfamily B member 5; CD85 antigen-like family member C; leukocyte immunoglobulin-like receptor 8

NCBI Summary for LILRB5

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Several other LIR subfamily B receptors are expressed on immune cells where they bind to MHC class I molecules on antigen-presenting cells and inhibit stimulation of an immune response. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for LILRB5

LILRB5: May act as receptor for class I MHC antigens. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Immunoglobulin superfamily; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: integral to membrane

Molecular Function: transmembrane receptor activity

Biological Process: cell surface receptor linked signal transduction; immune system process; defense response

Research Articles on LILRB5

1. Observational study of gene-disease association. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-LILRB5 antibody

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies	Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
Osteoclast Differentiation Pathway antibodies	Osteoclast Differentiation Pathway Diagram
Osteoclast Differentiation Pathway antibodies	Osteoclast Differentiation Pathway Diagram

Organs/Tissues associated with anti-LILRB5 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>1 publications with LILRB5 and Blood