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SARM1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS611726

Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. SARM (SAM and ARM-containing protein), along with other molecules… More details

$850 / 0.1 mg +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
SARM (SARM1), Polyclonal Antibody
Full Product Name
Rabit anti-Human SARM (SAM and ARM-containing Protein)
Product Gene Name
anti-SARM1 antibody
Product Synonym Names
SARM; SAMD2; MyD88-5; KIAA0524; SARM; Sterile alpha and TIR motifcontaining protein 1; Sterile alpha and Armadillo repeat protein
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide.
Purity/Purification
Purified by immunoaffinity chromatography.
Concentration
1mg/ml (lot specific)
Specificity
Recognizes human SARM. Species Crossreactivity: mouse and rat
Preparation and Storage
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Chromosome Location
Chromosome: 17; NC_000017.10 (26698683..26728062). Location: 17q11
OMIM
607732
3D Structure
ModBase 3D Structure for Q6SZW1
Immunogen
Synthetic peptide corresponding to a fragment of residues within the following region aa640-690 near the C-terminus of human SARM. Species Sequence Homology: porcine, 86%.

Product Categories/Family for anti-SARM1 antibody

Antibodies; Abs to Toll Like Receptors (TLR)
Applications Tested/Suitable for anti-SARM1 antibody
ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-SARM1 antibody
Western Blot: 1-2ug/ml. Immunohistochemistry: (Paraffin) 2ug/ml

Western Blot (WB) of anti-SARM1 antibody

Western Blot analysis of Daudi cell lysates using MBS611726
Lane A: 0.5ug/mL
Lane B: 1ug/ml
Rabbit Anti-SARM1 Polyclonal Antibody – Cat# MBS611726

Immunohistochemistry (IHC) of anti-SARM1 antibody

Immunohistochemistry analysis of Daudi cells using MBS611726 SARM (2ug/ml).
Rabbit Anti-SARM1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS611726

Immunofluorescence (IF) of anti-SARM1 antibody

Immunofluorescence of SARM in Daudi cells MBS611726 (2 ug/mL).
Rabbit Anti-SARM1 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS611726

Product References and Citations for anti-SARM1 antibody

1. Vogel SN, Fitzgerald KA, and Fenton MJ. TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression. Mol. Interv. 2003; 3:466-77.
2. Takeda K, Kaisho T, and Akira S. Toll-like receptors. Annu. Rev. Immunol. 2003; 21:335-76.
3. Janeway CA Jr and Medzhitov R. Innate immunerecognition. Annu. Rev. Immunol. 2002; 20:197-216. 4. O'Neill LAJ, Fitzgerald FA, and Bowie AG. The Toll-IL-1 receptor adaptor family grows to five members. Trends in Imm. 2003; 24:286-9. 5. McGettrick AF and O'Neill LAJ. The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction. Mol Imm. 2004; 41:577-82.

Other Notes

Small volumes of anti-SARM1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SARM1 purchase

MBS611726 is an antibody targeting SARM1. Also known as Rabit anti-Human SARM (SAM and ARM-containing Protein). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SARM1. It may not necessarily be applicable to this product.

NCBI GI #
154090976
NCBI GeneID
23098
NCBI Accession #
NP_055892
UniProt Primary Accession #
Q6SZW1
UniProt Secondary Accession #
O60277; Q7LGG3; Q9NXY5
UniProt Related Accession #
Q6SZW1
GenBank Nucleotide #
NM_015077.3
NCBI Official Full Name
sterile alpha and TIR motif-containing protein 1
NCBI Official Synonym Full Names
sterile alpha and TIR motif containing 1
NCBI Official Symbol
SARM1
NCBI Official Synonym Symbols
SARM; SAMD2; MyD88-5
UniProt Protein Name
Sterile alpha and TIR motif-containing protein 1
UniProt Synonym Protein Names
Sterile alpha and Armadillo repeat protein; Sterile alpha motif domain-containing protein 2; MyD88-5; SAM domain-containing protein 2; Tir-1 homolog
Protein Family
Sterile alpha and TIR motif-containing protein
UniProt Gene Name
SARM1
UniProt Synonym Gene Names
KIAA0524; SAMD2; SARM; MyD88-5
UniProt Entry Name
SARM1_HUMAN
NCBI Protein Information
sterile alpha and TIR motif-containing protein 1; tir-1 homolog; SAM domain-containing protein 2; sterile alpha and Armadillo repeat protein; sterile alpha motif domain-containing protein 2; sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila

UniProt Comments for SARM1

SARM1: Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88- dependent pathway or non-TLR signaling. Negative regulator of NF- kappa-B and IRF activation. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 17q11

Cellular Component: microtubule; mitochondrion; axon; cytoplasm; dendrite; extrinsic to mitochondrial outer membrane; synapse; cytosol; cell junction

Biological Process: regulation of apoptosis; regulation of dendrite morphogenesis; MyD88-independent toll-like receptor signaling pathway; response to glucose stimulus; toll-like receptor signaling pathway; innate immune response; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway
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Research Articles on SARM1

1. SARM overexpression caused mitochondrial clustering which has also been observed in several cell death phenomenon.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SARM1 antibody

 Reference Product  PubMed Publications
 MYD88 antibody  >13 publications with SARM1 and MYD88
 TICAM1 antibody  >10 publications with SARM1 and TICAM1
 TICAM2 antibody  >7 publications with SARM1 and TICAM2
 RS1 antibody  >1 publications with SARM1 and RS1

Pathways associated with anti-SARM1 antibody

 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway antibodies  Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway Diagram
 IKK Complex Recruitment Mediated By RIP1 Pathway antibodies  IKK Complex Recruitment Mediated By RIP1 Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 MyD88-independent Cascade Pathway antibodies  MyD88-independent Cascade Pathway Diagram
 TRAF6 Mediated Induction Of TAK1 Complex Pathway antibodies  TRAF6 Mediated Induction Of TAK1 Complex Pathway Diagram
 TRIF-mediated TLR3/TLR4 Signaling Pathway antibodies  TRIF-mediated TLR3/TLR4 Signaling Pathway Diagram
 Toll Like Receptor 3 (TLR3) Cascade Pathway antibodies  Toll Like Receptor 3 (TLR3) Cascade Pathway Diagram
 Toll Like Receptor 4 (TLR4) Cascade Pathway antibodies  Toll Like Receptor 4 (TLR4) Cascade Pathway Diagram

Diseases associated with anti-SARM1 antibody

 Disease Name  Pubmed Publications
 Death Antibodies  >5 publications with SARM1 and Death
 Inflammation Antibodies  >2 publications with SARM1 and Inflammation
 Neoplasms Antibodies  >2 publications with SARM1 and Neoplasms
 Nervous System Diseases Antibodies  >1 publications with SARM1 and Nervous System Diseases
 Necrosis Antibodies  >1 publications with SARM1 and Necrosis

Organs/Tissues associated with anti-SARM1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >5 publications with SARM1 and Brain
 Kidney Antibodies  >3 publications with SARM1 and Kidney
 Eye Antibodies  >2 publications with SARM1 and Eye
 Ganglia Antibodies  >1 publications with SARM1 and Ganglia
 Spleen Antibodies  >1 publications with SARM1 and Spleen
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