Natural Resistance Associated Macrophage Protein (SLC11A1) Antibody – Rabbit Polyclonal

SLC11A1: Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes. Belongs to the NRAMP family.

Protein type: Transporter, SLC family; Membrane protein, integral; Membrane protein, multi-pass; Vesicle; Transporter; Cell surface

Cellular Component: phagocytic vesicle membrane; cell surface; membrane; lysosome; late endosome; plasma membrane; integral to membrane; endosome membrane; vacuole

Molecular Function: transition metal ion transmembrane transporter activity; protein homodimerization activity; transporter activity; manganese ion transmembrane transporter activity; metal ion:hydrogen antiporter activity

Biological Process: respiratory burst; positive regulation of T-helper 1 type immune response; wound healing; cellular iron ion homeostasis; positive regulation of dendritic cell antigen processing and presentation; manganese ion transport; response to lipopolysaccharide; defense response to Gram-negative bacterium; antigen processing and presentation of peptide antigen; vacuolar acidification; nitrite transport; transport; T cell proliferation during immune response; T cell cytokine production; positive regulation of phagocytosis; interleukin-3 production; inflammatory response; positive regulation of cytokine production; mRNA stabilization; MAPKKK cascade; L-arginine import; defense response to protozoan; interleukin-2 production; iron ion transport; phagocytosis; cellular cadmium ion homeostasis; MHC class II biosynthetic process; positive regulation of interferon-gamma production; iron ion homeostasis; macrophage activation; response to bacterium; protein import into nucleus, translocation; negative regulation of cytokine production; defense response to bacterium; activation of protein kinase activity; ion transport; positive regulation of transcription from RNA polymerase II promoter